Many factors, one of which is drug toxicity, can cause liver damage. The metabolism of the analgesic/antipyretic paracetamol in the liver can result in liver toxicity. Curcumin and gingerol, two active compounds found in natural products, have been shown to be antioxidants. The objective of this study was to examine how curcuma, turmeric, and red ginger in traditional liquid medicine (TLM) affected the antioxidant and hepatoprotective effects of paracetamol-induced liver damage in rats. In rats treated with paracetamol with or without TLM, levels of the enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and malondialdehyde (MDA) were assayed. Silymarin (a milk thistle derivative with possible hepatoprotective effects) was used as a positive (treated) control. In comparison to the negative control group (paracetamol alone), the TLM was able to prevent a significant rise in MDA. The best prevention was with a TLM dose of 10.08 mL/KgBW, with an 87.80 percent prevention of increased plasma MDA levels. Compared to the negative group, this dose also showed the highest hepatoprotective activity as reflected by AST and ALT levels decreasing by 35.4 percent and 51.2 percent, respectively. In addition, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was used to evaluate the antioxidant activity of traditional medicinal products. TLC-Densitometry was utilized to analyze curcumin marker compounds, whereas High Performance Liquid Chromatography (HPLC) was used to analyze gingerol. Using the DPPH method, the IC50 value of TLM was 74.0658 ppm. TLM’s marker compound contained 1.325 percent curcumin and 0.20 percent gingerol. by decreasing MDA, AST and ALT levels, it can be concluded that TLM, which contains curcuma, turmeric, and red ginger, has potential antioxidant and hepatoprotective activity in rats induced by paracetamol.
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7 March 2024
THE 7TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: The 15th Asian Congress on Biotechnology in conjunction with the 7th International Symposium on Biomedical Engineering (ACB-ISBE 2022)
2–6 October 2022
Bali, Indonesia
Research Article|
March 07 2024
The hepatoprotective effect of traditional liquid medicine containing curcuma, turmeric, and red ginger on rat liver damage with paracetamol-induced hepatotoxicity
Umi Marwati;
Umi Marwati
1
Faculty of Pharmacy, Pancasila University
, South Jakarta, DKI Jakarta, 12640, Indonesia
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Dian Ratih Laksmitawati;
Dian Ratih Laksmitawati
a)
1
Faculty of Pharmacy, Pancasila University
, South Jakarta, DKI Jakarta, 12640, Indonesia
2
Center for Study of Natural Product for Degenerative Disease
, Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640 Indonesia
a)Corresponding author: [email protected]
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Diah Kartika Pratami;
Diah Kartika Pratami
1
Faculty of Pharmacy, Pancasila University
, South Jakarta, DKI Jakarta, 12640, Indonesia
2
Center for Study of Natural Product for Degenerative Disease
, Faculty of Pharmacy, Pancasila University, South Jakarta, DKI Jakarta, 12640 Indonesia
3
National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia
, Kampus UI Depok, 16424, West Java, Indonesia
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Ican Narua Nahya;
Ican Narua Nahya
1
Faculty of Pharmacy, Pancasila University
, South Jakarta, DKI Jakarta, 12640, Indonesia
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Olyvia Nur Azizah;
Olyvia Nur Azizah
1
Faculty of Pharmacy, Pancasila University
, South Jakarta, DKI Jakarta, 12640, Indonesia
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Muhamad Sahlan;
Muhamad Sahlan
4
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia
, Kampus UI Depok, 16424, West Java, Indonesia
5
Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia
, Kampus UI Depok, West Java 16424 Indonesia
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Abdul Mun’im;
Abdul Mun’im
3
National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia
, Kampus UI Depok, 16424, West Java, Indonesia
6
Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia
, Cluster of Health Sciences Building, Depok, West Java 16424, Indonesia
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Asep Bayu
Asep Bayu
3
National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia
, Kampus UI Depok, 16424, West Java, Indonesia
7
Research Center for Vaccine and Drugs, National Research and Innovation Agency
, Jalan Raya Jakarta Bogor KM. 46, Cibinong, Bogor, West Java 16911, Indonesia
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a)Corresponding author: [email protected]
AIP Conf. Proc. 3080, 090003 (2024)
Citation
Umi Marwati, Dian Ratih Laksmitawati, Diah Kartika Pratami, Ican Narua Nahya, Olyvia Nur Azizah, Muhamad Sahlan, Abdul Mun’im, Asep Bayu; The hepatoprotective effect of traditional liquid medicine containing curcuma, turmeric, and red ginger on rat liver damage with paracetamol-induced hepatotoxicity. AIP Conf. Proc. 7 March 2024; 3080 (1): 090003. https://doi.org/10.1063/5.0199353
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