Novel chalcone synthesis from phloroglucinol and its activity against multidrug resistance strain of S. aureus and E. coli

Antibiotic resistance was still a problem in curing infectious diseases, especially infections by pathogenic bacteria. Various studies to improve the quality of antibiotics by minimizing the minimum inhibitory concentration (MIC) value was still developed. One of the natural compounds that has antibiotic ability and has been widely developed was chalcone. This study aims to evaluate the combination effects of chalcone derivatives compounds that The compunds that have beeb synthesis were (E)-1-(2-hydroxy-4,6dimethoxyphenyl)-3-phenylprop-2-en-1-one(3a); (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4methoxyphenyl) prop-2-en-2-one(3b); and (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl) prop-2en-1-one (3c) with antibiotics (ciprofloxacin, ampicillin, and doxycycline) by reducing the MIC value in Staphylococcus aureus and Escherichia coli. The results of this study indicate that the combination of chalcone derivatives and antibiotics could significantly reduce the MIC value.