This study investigates the effect of using the “Go-Chemist!” on students’ self-efficacy regarding chemistry and technology on hydrocarbons. This study used a quasi-experimental pre-test-posttest design. The respondents were 72 students (25 males and 47 females) at a public high school in Jakarta, Indonesia. Students in the experimental group (n = 36) were instructed to use the “Go-Chemist!” app, and students in the control group (n = 36) were taught using printed textbooks. All students in both groups completed the Self-Efficacy Scale towards Science and Technology (SESST) before and after the intervention to measure their level of self-efficacy on the topic of hydrocarbons. Independent and paired sample t-tests were used to analyze the difference and increase in scores between the experimental and control groups. The results reflected that students in the experimental group were superior, and there was a significant increase in the mean score compared to the control group concerning self-efficacy. Based on the findings, we recommend that teachers and students use the “Go-Chemist!” app to promote students’ self-efficacy toward chemistry and technology on the topic of hydrocarbons to a satisfactory level.

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