Indonesian biodiversity is enriched by the numerous medicinal plants, including those growing on the island of Papua. We review the pharmacological potency of several medicinal plants from Papua by determining the total phenolic and flavonoid content from ethanol extracts. Several parts were used from Sphaerostephanos sp (leaves), Albizia procera (Roxb) Benth (leaves, stem, and roots), Carica papaya L (leaves), Bideris pilosa L (leaves), Cymbopogonicitratus (DC) (leaves), Annona muricata L (leaves (Anne)), Macaranga tanarius Muell Arg (leaves), and Premna sp (eaves). Total phenolic content was estimated using the Folin-Ciocalteu method, while the flavonoid content was measured using the common colorimetric method. The current study indicates that Sphaerostephanos sp. has the highest flavonoid content (26.118 ± 0.160 mg quercetin equivalents/g dried extract). At the same time, the leaves of Carica papaya L and stem of Albizia procera (Roxb) Benth contain the highest phenolic content (15.410 ± 9.269 and 15.410 ± 0.978 gallic acid equivalents/ g dried extract, respectively). The results presented here indicate that plants from Papua have pharmacological properties, and may be related to the flavonoid and phenolic content. The potency of Albizia procera L., Annona muricata L., Bidens pilosa L., Carica papaya L., Macaranga tanarius L., Sphaerostephanos unitus (L). Holttum, Premna integrifolia L., Premna fulva Craib, and Premna integrifolia as complementary medicines derived from ethnopharmacology and scientific literature requires further studies.

1.
K.
Muller
,
Keragaman Hayati Tanah Papua
. (
Universitas Negeri Papua
,
Manokwari
,
2005
).
2.
N.
Handayani
,
Etnofarmakologi papua.
2014
.
3.
Dinas Kesehatan Provinsi Papua sentra penembangan dan penerapan pengobatan tradisinal (SP3T)
,
Buku Tumbuhan Kerarifan Lokal Papua/Papua traditional medicine herbs. Nulis buku jendela ilmiah
, 1st ed. (
Dinas Kesehatan Provinsi Papua
,
2016
)
4.
A.
Maruzy
and
R.
Mujahid
,
Media Konserv.
24
,
114
23
(
2019
).
5.
S.
Mani
,
C.
Duraipandian
, and
S.B.
Chidambaram
,
BMC Complement. Med. Ther.
22
,
50
(
2022
).
6.
Y.
He
,
Q.
Wang
,
Y.
Ye
,
Z.
Liu
, and
H.
Sun
,
J. Ethnopharmacol.
257
,
112677
(
2020
).
7.
S.P.
Singh
,
S.
Kumar
,
S. V.
Mathan
,
M.S.
Tomar
,
R.K.
Singh
,
P.K.
Verma
,
A.
Kumar
,
S.
Kumar
,
R.P.
Singh
, and
A.
Acharya
,
DARU J. Pharm. Sci.
28
,
735
(
2020
).
8.
O.R.
Alara
,
N.H.
Abdurahman
, and
J.A.
Alara
,
Adv. Tradit. Med.
22
,
17
(
2020
).
9.
T.D.
Xuan
and
T.D.
Khanh
,
J. Pharm. Investig.
46
,
91
(
2016
).
10.
A.P.
Bartolome
,
I.M.
Villaseñor
, and
W.-C.
Yang
,
Evidence-Based Complement. Altern. Med.
2013
,
1
(
2013
).
11.
M.
Mutakin
,
R.
Fauziati
,
F.N.
Fadhilah
,
A.
Zuhrotun
,
R.
Amalia
, and
Y.E.
Hadisaputri
,
Molecules
27
,
1201
(
2022
).
12.
S.M. Abdul
Wahab
,
I.
Jantan
,
M.A.
Haque
, and
L.
Arshad
,
Front. Pharmacol.
9
(
2018
).
13.
K.
Yoshimura
,
T.
Hosoya
,
M.
Fujinami
,
T.
Ohta
, and
S.
Kumazawa
,
Phytomedicine
36
,
238
(
2017
).
14.
M.
Shahinozzaman
,
D.N.
Obanda
, and
S.
Tawata
,
Phyther. Res.
35
,
207
(
2021
).
15.
A. N.
Panche
,
A. D.
Diwan
,
S. R.
Chandra
,
J. Nutr. Sci.
5
,
1
15
(
2016
)
16.
Q.-W.
Zhang
,
L.-G.
Lin
, and
W.-C.
Ye
,
Chin. Med.
13
,
20
(
2018
).
17.
H. Y.
Kim
and
K.
Kim.
J. Agric, Food Chem.
51
,
1586
1591
(
2003
).
18.
A.
Septembre-Malaterre
,
G.
Stanislas
,
E.
Douraguia
, and
M. P.
Gonthier
,
Food Chem.
212
,
225
233
(
2016
), doi: .
19.
R.
Pinnamaneni
,
World J. Pharm. Pharm. Sci.
6
,
2559
72
(
2017
).
20.
A.
Nariya
and
D.
Jhala
,
Int. Res. J. Pharm.
8
,
13
6
(
2017
).
21.
N.
Sudhakar
and
Theivanai
,
Int. J. Pharm. Pharm. Sci.
6
, (
2014
).
22.
T. T. T.
Nguyen
,
P. N.
Shaw
,
M.-O.
Parat
, and
A. K.
Hewavitharana
,
Mol. Nutr. Food Res
57
,
153
64
(
2013
).
23.
J. A. O.
Okeniyi
,
T. A.
Ogunlesi
,
O. A.
Oyelami
, and
L. A.
Adeyemi
,
J. Med. Food
10
,
194
196
(
2007
), doi: .
24.
S.
Pandey
,
P. J.
Cabot
,
P. N.
Shaw
, and
A.
Hewavitharana
,
Journal of Immunotoxicology
13
(
4
),
590
602
(
2016
).
25.
S.
Rajapakse
,
N. L.
De Silva
,
P.
Weeratunga
,
C.
Rodrigo
,
C.
Sigera
, and
S. D.
Fernando
,
BMC Complement. Altern. Med.
19
,
1
9
(
2019
)
26.
A. H.
Amin
et al
J. Food Biochem.
43
,
1
11
(
2019
)
27.
S.
Lidiani
F et al
Nutrients
59
,
267
286
(
2014
).
29.
M.
Sangeetha
,
D.
Chamundeeswari
,
C. Saravana
Babu
,
C.
Rose
, and
V.
Gopal
.
J. Ethnopharmacol.
250
, (
2020
), doi: .
30.
F. R.
Melek
,
T.
Miyase
,
N. S.
Ghaly
, and
M.
Nabil
,
Phytochemistry
68
,
1261
1266
(
2007
).
31.
M. M.
Khatoon
,
M. H.
Khatun
,
M. E.
Islam
, and
M. S.
Parvin
,
Asian Pac. J. Trop. Biomed.
4
,
279
284
(
2014
).
32.
T.
Miyase
,
F. R.
Melek
,
N. S.
Ghaly
,
T.
Warashina
,
M.
El-Kady
, and
M.
Nabil
,
Phytochemistry
71
,
1375
1380
(
2010
), doi: .
33.
P.
Panthong
et al
Pharm. Biol.
53
,
1861
1866
(
2015
).
34.
35.
K.
Yoshikawa
,
Y.
Satou
,
Y.
Tokunaga
,
M.
Tanaka
,
S.
Arihara
, and
S. K.
Nigam
,
J. Nat. Prod.
61
,
440
445
(
1998
).
36.
A. S.
Lubaina
,
N. D.
Brijithlal
, and
K.
Murugan
,
World J. Pharm. Res.
5
,
841
52
.
37.
R.
Dianita
and
I.
Jantan
,
Pharm Biol.
55
,
1715
1739
(
2017
).
39.
C.
Singh
,
J.
Kumar
,
P.
Kumar
,
B.S.
Chauhan
,
K.N.
Tiwari
, and
S.K.
Mishra
,
Biotechnol. Biotechnol. Equip.
33
,
359
371
(
2019
).
40.
Y. S.
Wang
,
H.
Zhang
,
K. W.
Wang
,
T. T.
Zhang
, and
X. F.
Fan
,
Chem. Nat. Compd.
56
,
373
375
(
2020
).
41.
R.
Azad
,
N. K.
Babu
,
A. D.
Gupta
, and
P.
Reddanna
,
Fitoterapia
131
,
189
199
(
2018
).
42.
G.
Yahaya
,
F.
Abou-Elella
,
F.
Wamunyokoli
, and
H.
Ael-Shemy
,
Asian Pac. J. Trop Med.
7
,
355
363
(
2014
).
43.
M.Y.
Ovando-Domínguez
,
M.C.
Luján-Hidalgo
,
D.
González-Mendoza
,
A.A.
Vargas-Díaz
,
N.
Ruiz-Lau
,
F.A.
Gutiérrez-Miceli
, et al
Phyton
88
,
139
147
(
2019
).
44.
H.H.
Orak
,
I.S.
Bahrisefit
, and
T.
Sabudak
,
Pol. J. Food Nutr. Sci.
69
,
359
366
(
2019
).
45.
A.B.
Justino
,
N.C.
Miranda
,
R.R.
Franco
,
M.M.
Martins
,
N.M.
Silva da
, and
F.S.
Espindola
,
Biomed Pharmacother
,
100
,
83
92
(
2018
).
46.
S. Z.
Moghadamtousi
,
M.
Fadaeinasab
,
S.
Nikzad
,
G.
Mohan
,
H. M.
Ali
, and
H. A.
Kadir
,
Int. J. Mol Sci.
16
,
15625
15658
(
2015
).
47.
I.
Rady
,
M. B.
Bloch
,
R.C.N.
Chamcheu
,
S. Banang
Mbeumi
,
M. R.
Anwar
,
H.
Mohamed
, et al
Oxid Med Cell Longev.
2018
(
2018
).
48.
S.U.F. Syed
Najmuddin
,
M.F.
Romli
,
M.
Hamid
,
N.B.
Alitheen
, and
N.M.A.N. Abd
Rahman
,
BMC Complement Altern Med.
16
,
1
20
(
2016
).
49.
A.I.
Yajid
,
H.S. Ab
Rahman
,
M.P.K.
Wong
, and
W.Z. Wan
Zain
,
Malaysian J. Med. Sci.
25
,
5
15
(
2018
).
50.
W.J.J.
Chan
,
A.J.
McLachlan
,
J.R.
Hanrahan
, and
J.E.
Harnett
,
J. Pharm Pharmacol.
72
,
1
16
(
2020
).
51.
A. N.
Satia
,
Y.D.
Damayanti
,
P.
Wangchuk
, and
P.A.
Keller
,
Molecules
24
,
4419
(
2019
).
52.
K.
Matsunami
,
I.
Takamori
,
T.
Shinzato
,
M.
Aramoto
,
K.
Kondo
,
H.
Otsuka
, et al
Chem Pharm Bull.
54
,
1403
1407
(
2006
).
53.
J.
Lee
and
L.
Zhang
,
Protein Cell
6
,
26
41
(
2015
).
54.
S.
Phommart
,
P.
Sutthivaiyakit
,
N.
Chimnoi
,
S.
Ruchirawat
, and
S.
Sutthivaiyakit
,
J. Nat Prod.
68
,
927
930
(
2005
).
55.
T.M.H.
Doan
,
T.L.
Nguyen
,
T.T. Trinh
Van
,
V.N.
Vu
,
T.D.
Phi
,
M.
Litaudon
, et al
J. Anal Methods Chem.
2019
,
7
12
(
2019
).
56.
T.
Péresse
,
G.
Jézéquel
,
P.M.
Allard
,
V.C.
Pham
,
D.T.M.
Huong
,
F.
Blanchard
, et al
J. Nat Prod.
80
,
2684
2691
(
2017
).
57.
S.I.
Wada
and
R.
Tanaka
,
Chem Biodivers.
3
,
473
479
(
2006
).
58.
M. A. A.
Johnson
,
C. X.
Madona
,
R. S.
Almeida
,
N.
Martins
, and
H. D. M.
Coutinho
,
Antibiotics
9
,
1
13
(
2020
).
59.
B. K.
Ghimire
,
J. H.
Yoo
,
C. Y.
Yu
, and
I. M.
Chung
,
Asian Pac J Trop Med.
10
,
643
651
(
2017
).
60.
G.
Aravind
,
D.
Bhowmik
,
S.
Duraivel
, and
G.
Haris
,
J. Med. Plants Stud.
1
,
7
15
(
2013
).
61.
S.
Sivakrishnan
and
M.
Swamivelmanickam
,
J. Glob Pharma Technol.
11
(
2019
).
62.
P.
Pant
,
S.
Pandey
, and
S.
Dall’Acqua
,
Chem. Biodivers.
18
(
2021
).
63.
M.
Zhang
,
D.
Jiang
,
M.
Yang
,
T.
Ma
,
F.
Ding
,
M.
Hao
,
Y.
Chen
,
C.
Zhang
,
X.
Zhang
, and
M.
Li
,
Front. Plant Sci.
12
(
2021
).
64.
A.
Nurcahyanti
,
Pharmacogn Rev.
13
,
16
23
(
2019
).
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