Holmium-166 (166Ho) is one of theranostic radionuclides that was potential for use in nuclear medicine applications. This radiolanthanide can be produced in nuclear reactor through direct or indirect methods. Radioisotope of 166Ho produced from indirect method is a carrier free, so that it has a high specific activity which can be separated from irradiated target. The preliminary study for separation of 166Ho through indirect method from irradiated natural dysprosium oxide (Dy2O3) target at TRIGA 2000 Bandung reactor has been carried out. The separation of 166Ho radionuclide from Dy/Ho matrix of irradiated Dy2O3 target was obtained using extraction chromatography method with LN resin which has a particle size of 50-100 µm as a stationary phase, while nitric acid solution was used as a mobile phase. The purpose of this study is to obtain the separation condition of 166Ho from irradiated natural Dy2O3 target with various amounts of LN resin and concentrations of nitric acid solutions at room temperature. The irradiated of natural Dy2O3 target contained 166Ho, 166Dy and 157Dy radionuclides of 75.10%, 24.56% and 0.34%, respectively. The separation condition with 1.4 N HNO3 (fraction 1-53) and 3 N HNO3 (fraction 54-80) solutions using 3 g of LN resin obtained 166Ho radionuclide with a yield of 40.35±1.23%. The radioisotope of 166Ho obtained from the separation has a high radionuclide purity of 100 %.
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15 February 2024
INTERNATIONAL CONFERENCE ON NUCLEAR SCIENCE, TECHNOLOGY, AND APPLICATIONS – ICONSTA 2022
23–24 November 2022
Tangerang Selatan, Indonesia
Research Article|
February 15 2024
Preliminary study for separation of Holmium-166 radioisotope from irradiated natural dysprosium oxide target at TRIGA 2000 Bandung reactor
Azmairit Aziz;
Azmairit Aziz
a)
1
Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry Technology, Research Organization for Nuclear Energy
, National Research and Innovation Agency (BRIN) South Tangerang 15314, Indonesia
a)Corresponding author: [email protected]
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Almira Fathadina
Almira Fathadina
b)
2
School of Pharmacy - Bandung Institute of Technology
Jl. Ganesa 10, Bandung 40132, Indonesia
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a)Corresponding author: [email protected]
AIP Conf. Proc. 2967, 210002 (2024)
Citation
Azmairit Aziz, Almira Fathadina; Preliminary study for separation of Holmium-166 radioisotope from irradiated natural dysprosium oxide target at TRIGA 2000 Bandung reactor. AIP Conf. Proc. 15 February 2024; 2967 (1): 210002. https://doi.org/10.1063/5.0193706
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