The need for healthy and safe fresh fruits of citrus, apples, strawberries, and grapes is increasing during the COVID-19 pandemic. The decrease in quality during storage is mainly caused by postharvest fungi, which have the potential to produce mycotoxins that are harmful to human health. The application of synthetic fungicides remains the most effective method for controlling postharvest pathogens. However, its use is increasingly restricted internationally. Currently, greater attention is being paid to natural flora as an alternative to botanical fungicides in disease management. Different parts of medicinal plants have different phytochemicals and antioxidants that can be used in plant protection and preservation. This paper reviews the prospects of medicinal plant extracts for postharvest protection and preservation of citrus and subtropical fruits in Indonesia. There are 31 types of spice and medicinal plants found in Indonesia that have the potential to control post-harvest diseases. Extracts from Cymbopogon nardus, Ruta chalepensis, Eucalyptus globulus, etc., were effective in controlling post-harvest pathogens of fruit and increasing their shelf life. Extracts of neem and marigold also have the potential to contain dominant active ingredients such as insecticides and fungicides. These plant materials are recommended for the prevention of post-harvest diseases. Constraints of mass production as a commercial because of the low content of secondary metabolites, so it requires a massive supply of raw materials. The implication for developing further research is that technology needs to increase the content of secondary metabolites, determine safer dosage limits, and overcome allergy challenges.

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