Ocular medication delivery is the main issue facing pharmacologists and formulation scientists today. The most practical and patient-friendly drug delivery method, particularly again for management of diseases of the anterior segment, is topical eye drops. Various precorneal, dynamic, and static ocular barriers prevent medication delivery to the specific ocular tissues. Additionally, target tissues do not retain therapeutic medication levels for a a lengthy time frame.

The development of innovative, secure, and patient-compliant medication formulations and therapeutic agents instruments, which can overcome these obstacles and sustain medication levels in tissues, has increased over the past two decades in the field of ocular drug delivery research. The medicine was directly injected into the posterior part of the eye via intravitreal injection, a procedure that is invasive and has significant side effects. Therefore, a less intrusive medication delivery method should target the posterior part of the eye. The medication distribution concept was developed and simulated using commercial finite element software employing a micro-channels module inserted between top and bottom covers with a drug reservoir (COMSOL).

We outline the general strategies for the current implant device-based treatments utilized to treat retinal disorders in this study. We provide our opinions on potential approaches and difficulties for creating more potent device-based treatments for retinal disorders.

1.
J. A.
Byford
,
Z.
Purtill
and
P.
Chahal
, "
Fabrication of Terahertz Components Using 3D Printed Templates
,"
2016 IEEE 66th Electronic Components and Technology Conference (ECTC)
,
Las Vegas, NV
,
USA
,
2016
, pp.
817
822
, doi: .
2.
Lee
J.H.
,
Pidaparti
R.M.
,
Atkinson
G.M.
,
Moorthy
RS
.
Design of an implantable device for ocular drug delivery
.
J Drug Deliv.
2012;
2012
:
527516
. doi: .
3.
Lo
R.
,
Li
P.Y.
,
Saati
S.
,
Agrawal
R.N.
,
Humayun
M.S.
,
Meng
E.
A passive MEMS drug delivery pump for treatment of ocular diseases
.
Biomed Microdevices.
2009
Oct;
11
(
5
):
959
70
. doi: .
4.
Ma
,
Yongting
&
Pidaparti
,
Ramana
. (
2014
).
Simulation of Drug-Loaded Nanoparticles Transport Through Drug Delivery Microchannels
.
Journal of Nanotechnology in Engineering and Medicine.
5
.
031002
. .
5.
Muthukumar
,
V.
&
Venkatasamy
,
R.
&
Mariselvam
,
V.
&
Senthilkumar
,
N.
&
Fernando
,
Antony
& A,
Suresh
babu
. (
2014
).
Comparative Investigation on Mechanical Properties of Natural Fiber Reinforced Polyester Composites
.
Applied Mechanics and Materials.
592
594
. 92-96. .
6.
Patel
A.
,
Cholkar
K.
,
Agrahari
V.
,
Mitra
AK
.
Ocular drug delivery systems: An overview
.
World J Pharmacol.
2013
;
2
(
2
):
47
64
. doi: . PMID:
[PubMed]
; PMCID:
[PubMed]
.
7.
Goudie
M.J.
,
Ghuman
A.P.
,
Collins
S.B.
,
Pidaparti
R.M.
,
Handa
H.
Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications
.
J Drug Deliv.
2016;
2016
:
7913616
. doi: . Epub 2016 May 26. PMID:
[PubMed]
; PMCID:
[PubMed]
.
8.
Pidaparti
,
Ramana
&
Lee
,
Jae-Hwan
&
Yang
,
Hu
. (
2014
).
Micro-channel diffusion characteristics of an implantable drug delivery device for age-related macular degeneration
.
Microsystem Technologies.
21
. .
9.
Achouri
D.
,
Alhanout
K.
,
Piccerelle
P.
,
Andrieu
V.
Recent advances in ocular drug delivery
.
Drug Dev Ind Pharm.
2013
Nov;
39
(
11
):
1599
617
. doi: . Epub 2012 Nov 16. PMID:
[PubMed]
.
10.
Lang
,
John
C.
"
Ocular drug delivery conventional ocular formulations
."
Advanced drug delivery reviews
16
.
1
(
1995
):
39
43
.
11.
Sahoo
S.K.
,
Dilnawaz
F.
,
Krishnakumar
S.
Nanotechnology in ocular drug delivery
.
Drug Discov Today.
2008
Feb;
13
(
3-4
):
144
51
. doi: . PMID:
[PubMed]
.
12.
Lo
R.
,
Li
P.Y.
,
Saati
S.
,
Agrawal
R.N.
,
Humayun
M.S.
,
Meng
E.
A passive MEMS drug delivery pump for treatment of ocular diseases
.
Biomed Microdevices.
2009
Oct;
11
(
5
):
959
70
. doi: . Epub 2009 Apr 25. PMID:
[PubMed]
.
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