Comparative analysis of Ca²⁺, K⁺ and Na⁺ channels roles in action potential generation of sinoatrial nodes using Rungekutta method

Aim: To examine the calcium, potassium and sodium molecules film potential to redirect impacts in atrial nodes Electrocardiogram (ECG) age for the customary and strange condition using Rungekutta strategy. Materials and Methods: In this research human atrial cells are based on Seemann et al. method can be used to describe the action potential model of sinoatrial nodes. Sample size can be calculated as 70 and the G power is 80%. Numerical conditions of calcium, potassium and sodium channels can be done by the RungeKutta strategy. Results: The typical film capability of calcium is -30 mV, but for the different parameters expanding of 100%, half and 25%, the layer possibilities are -52 mV, -26 mV and -42 mV and afterward the diminishing of 100% and half calcium levels doesn’t frame single ECG waveform, diminishing of 25%, the layer potential is -45 mV. The normal film ability of potassium is 3.3 mV, but for the different parameters growing of 100%, half and 25%, the layer prospects are 6.4 mV, 4.8 mV and 4 mV and subsequently the decreasing of 100% potassium levels doesn’t outline single ECG waveform, reducing of half and 25%, the layer possibilities are 4 mV and 3 mV. The regular film limit of sodium is 81.2 mV, but for the different parameters stretching out of 100%, half and 25%, the layer possibilities are 162.4 mV, 121.8 mV and 101.5 mV and from there on the diminishing of 100% sodium levels doesn’t diagram single ECG waveform, diminishing of half and 25%, the layer prospects are 40 mV and 37.7 mV. By contrasting these qualities there is a distinction in pacemaking action and causes sporadic heartbeat and prolongation happens. In typical Action Potential, the withdrawal will happen routinely. In unusual AP, the conduction of electrical excitation will contrast and make sporadic heart work cause arrhythmia. Later on, a superior comprehension of the cell model can be utilized to identify the medication that assists with making a typical heartbeat.