This study aims to determine the efficacy of Aloe vera gel against the deficiency in all of the white blood cells (leukopenia) and platelets (thrombocytopenia) that are induced by the effections of drugs(Methotrexate and Azathioprine) and provide the protection and treatment from this deficiency, if drugs are taken alone or in combination in cases that require it, where the results showed significantly reduced in platelets and white blood cell counts, compared with the control group, would be significantly raised by the treatment with the gel of Aloe vera orally.

1.
S.
Kumari
,“
Methotrexate induced hepatotoxicity and its management
,”.
Inter J Sci Res
5
:
1477
1481
(
2016
).
2.
FC.
Celik
,
M.
Gocmez
,
I.
Bozkurt
,
K.
Kaplan
and
E.
Kamasak
,“
Neuroprotective effects of carvacrol and pomegranate against methotrexate induced toxicity in rats
,”.
Eur Rev Med Pharmacol Sci
17
:
2988
2993
(
2013
).
3.
I. O.
Sherif
and
N. H.
Al-Shaalan
,“
Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis
,”.
Drug and Chemical Toxicology
,
1
9
(
2020
).
4.
M. F.
Schaalan
,
B. K.
Ramadan
and
A. H. Abd
Elwahab
, “
Ameliorative effect of taurine-chloramine in azathioprine-induced testicular damage; a deeper insight into the mechanism of protection
,”.
BMC complementary and alternative medicine
,
18
(
1
),
1
14
(
2018
).
5.
Z. F.
Bhat
,
S.
Kumar
and
P.
Kumar
,“
Effect of Aloe vera on the lipid stability and storage quality of chicken nuggets
,”.
Nutrition & Food Science
(
2015
).
6.
L. M.
Al-Abbassi
and
K. T.
Al-Hatemy
,“
characterization of some bioactive compounds from citrus limon (l.) and evaluating the biological effects on thyroid hormone and cellular toxicity
,”.
Pak. J. Biotechnol.
Vol
14
.
3
551
558
(
2017
).
7.
T.
Kanderi
,
J. C.
Gomez
,
M. M.
Puthenpura
,
K.
Yarlagadda
and
M.
Gangireddy
,“
Pancytopenia as a Complication of Low-Dose Methotrexate in a Septuagenarian
,”.
A Rare Presentation. Cureus
,
12
(
6
) (
2020
).
8.
A. Y. N.
Lim
,
K.
Gaffney
and
D. G. I.
Scott
,“
Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years
,”.
Rheumatology
,
44
(
8
),
1051
1055
(
2005
).
9.
N.
Morin-Crini
,
E.
Lichtfouse
,
G.
Torri
and
G.
Crini
,“
Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry
,”.
Environmental Chemistry Letters
,
17
(
4
),
1667
1692
(
2019
).
10.
P. P.
Bhise
and
G. V.
Zodape
,“
Effect of Aloe vera juice on the toxicity induced by isoniazid and rifampicin drugs on complete blood count in male wistar rats
,”.
International Journal of Pharmaceutical Sciences And Research
,
7
,
3728
3733
(
2016
).
11.
K.
Bradford
and
D. Q.
Shih
,“
Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease
,”.
World journal of gastroenterology: WJG
,
17
(
37
),
4166
(
2011
).
12.
S. Z.
Lim
and
E. W.
Chua
,“
Revisiting the role of thiopurines in inflammatory bowel disease through pharmacogenomics and use of novel methods for therapeutic drug monitoring
,”.
Frontiers in pharmacology
,
9
,
1107
(
2018
).
13.
N. K. H.
De Boer
,
C. J. J.
Mulder
and
A. A.
Van Bodegraven
,“
Myelotoxicity and hepatotoxicity during azathioprine therapy
,”.
Neth J Med
,
63
(
11
),
444
446
(
2005
).
14.
A.
Telm
,
E.
Schaeffeler
,
KR.
Herlinger
,
U.
Klotz
and
M.
Schwab
,“
Thiopurine treatment in inflammatory bowel disease
,”.
Clin Pharmacokinet
,
46
:
187
208
(
2007
).
15.
JF.
Colombel
,
N.
Ferrari
,
H.
Debuysere
,
P. Marteau JP.
Gendre
and
B.
Bonaz
,“
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
,”.
Gastroentrology
,
118
:
1025
30
(
2000
).
16.
J.
Kemmerling
,
E.
Fehlert
,
C. F.
Kuper
,
C.
Rühl-Fehlert
,
G.
Stropp
,
J.
Vogels
and
H. W.
Vohr
,“
The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties
,”.
European Journal of Pharmacology
,
759
,
326
342
(
2015
).
17.
H. W.
Smith
,
C. J.
Winstead
,
K. K.
Stank
,
B. W.
Halstead
and
D.
Wierda
, “
A predictive F344 rat immunotoxicology model: cellular parameters combined with humoral response to NP-CγG and KLH
,”.
Toxicology
,
194
(
1-2
),
129
145
(
2003
).
18.
G.
Molyneux
,
F. M.
Gibson
,
C. M.
Chen
,
H. K.
Marway
,
S.
McKeag
,
C. V.
Mifsud
and
J. A.
Turton
,“
The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse
,”.
International journal of experimental pathology
,
89
(
2
),
138
158
(
2008
).
19.
O.E.
Ofem
,
A.L. Udefa A.N.
Archibong
and
G.O.
Ujong
,“
Comparative effect of vitamin C and high calcium diet on some serum bio-markers of liver function in high salt loaded rats
,”.
Journal of pharmaceutical biology
,
7
(
2
):,
80
89
(
2017
).
20.
C. O.
Nku
,
O. E.
Ofem
and
U. A.
Okon
,“
Effect of prolong consumption of crude Aloe barbadensis (Aloe vera) gel on haematological indices in rats
,”.
Asian Journal of Medical Sciences
,
6
(
2
),
57
61
(
2015
).
21.
S. C.
Sweetman
,“
Dose adjustment in renal impairment: response from Martindale: the Complete Drug Reference
,”.
Bmj
,
331
(
7511
),
292
293
(
2005
).
22.
C. H.
Jensen
,
J.
Tiu
and
J. S.
Catalanotti
,“
Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers
,”.
BCR
(
2018
).
23.
M.
Ghalamkari
,
S. K.
Reyhan
,
N. K.
Rad
and
M.
Abbaszadeh
,“
Azathioprine-induced severe bone marrow suppression
,”.
Case Reports in Clinical Practice
(
2019
).
24.
N. E.
Daim
and
H. K.
Al-Mayali
,“
Effect of the rutin on azathioprine-induced toxicity in reproductive function male rats
,”.
Eurasian Journal of Biosciences
,
14
(
2
) (
2020
).
25.
B. A.
Mhatre
, and
T.
Marar
,“
Protective effect of Morinda citrifolia L.(fruit extract) on methotrexate-induced toxicities—hematological and biochemical studies
,”.
Cogent biology
,
2
(
1
),
1207879
(
2016
).
26.
N. N.
Patel
,
D. J.
Ghodasara
,
S.
Pandey
,
P. D.
Ghodasara
,
J. H.
Khorajiya
,
B. P.
Joshi
and
Dave
C. J.
,“
Subacute toxicopathological studies of methotrexate in Wistar rats
,”.
Veterinary World
, Vol.
7
(
7
), pp.
489
495
, (
2014
).
27.
B. Ekanade O. A.
Oridupa
and
M. O.
Oyeyemi
,“
Assessment of the safety of aqueous extract of Aloe vera on haematology of Wistar rats
,”.
African Journal of Biotechnology
,
14
(
30
),
2395
2399
(
2015
).
28.
BB.
Sen
,
EN.
Rifaioglu
,
O.
Ekiz
,
MU.
Inan
,
T.
Sen
and
N.
Sen
,“
Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis
,”.
Cutan. Ocul. Toxicol.
33
(
3
):
223
237
(
2013
).
29.
A. K.
Atteya
,
E. A.
Omer
,
E. A.
Genaidy
,
R.
Fouad
and
S. A.
Elnony
.
Middle East Journal of Agriculture Research
Volume: 10| Issue: 02| April-June| 2021.
Middle East J
,
10
(
2
),
654
673
(
2021
).
30.
P.
Mansouri
,
M.
Haghighi
,
N.
Beheshtipour
and
M.
Ramzi
, “
The effect of Aloe vera solution on chemotherapy-induced stomatitis in clients with lymphoma and leukemia: A randomized controlled clinical trial
,”.
International journal of community based nursing and midwifery
,
4
(
2
),
119
(
2016
).
This content is only available via PDF.
You do not currently have access to this content.