Different aspects of the use of mechanochemistry in the study of pharmaceutical materials are discussed, including the use of mechanical activation to modify the physical and chemical properties of drugs and the use of mechanochemical methods for solid-state synthesis of drugs. During grinding and tabulation, mechanochemical variables must be considered. A branch of solid-state chemistry known as mechanical chemistry studies processes that can occur in solids when mechanical energy is applied. The energy is provided by high-energy milling. Mechanochemical approaches produce a variety of surface and bulk defects in treated solids, which intensifies the course of processes. A milling process accumulates energy which can be used in a subsequent process. Mechanochemistry has the potential to be utilized in cases where the economic demand, the high temperature as well as wet processes may need to be considered. It will be demonstrated how a mechanochemical approach can be applied to such widely diverse fields as extractive metallurgy, materials engineering, and medicine. The aim of this review is to show how mechanochemical techniques have advanced the development of new solid forms as well as a structural understanding of these forms, plus the use of supramolecular strategies to create pharmaceutical solid forms.
Skip Nav Destination
Article navigation
4 December 2023
2ND INTERNATIONAL CONFERENCE OF MATHEMATICS, APPLIED SCIENCES, INFORMATION AND COMMUNICATION TECHNOLOGY
1–2 May 2022
Baghdad, Iraq
Research Article|
December 04 2023
A review of solid state mechanochemistry for drug synthesis and modification
Mohammad Alrbaihat
Mohammad Alrbaihat
a)
1
Teacher Training Institute, Emirates School Establishment
, Dubai, 3962, United Arab Emirates
a)Corresponding author: [email protected]
Search for other works by this author on:
a)Corresponding author: [email protected]
AIP Conf. Proc. 2834, 030019 (2023)
Citation
Mohammad Alrbaihat; A review of solid state mechanochemistry for drug synthesis and modification. AIP Conf. Proc. 4 December 2023; 2834 (1): 030019. https://doi.org/10.1063/5.0161815
Download citation file:
Pay-Per-View Access
$40.00
Sign In
You could not be signed in. Please check your credentials and make sure you have an active account and try again.
Citing articles via
Inkjet- and flextrail-printing of silicon polymer-based inks for local passivating contacts
Zohreh Kiaee, Andreas Lösel, et al.
Design of a 100 MW solar power plant on wetland in Bangladesh
Apu Kowsar, Sumon Chandra Debnath, et al.
Effect of coupling agent type on the self-cleaning and anti-reflective behaviour of advance nanocoating for PV panels application
Taha Tareq Mohammed, Hadia Kadhim Judran, et al.
Related Content
FT-IR spectroscopy key features for characterization of 1:1 layer silicate minerals: A review
AIP Conf. Proc. (September 2023)
A new compact symmetric shear diamond anvil cell for in situ high-pressure-torsion studies
Rev. Sci. Instrum. (May 2024)
Multifractal properties of ball milling dynamics
Chaos (May 2014)
Peculiarities of obtaining nanocomposites with organic additives and consolidated nanomaterials with given properties
Low Temp. Phys. (November 2023)
Preface: International Conference on Advances in Material Science and Chemistry (ICAMSC – 2023)
AIP Conf. Proc. (July 2024)