Osteoporosis is one of the systemic diseases present by a decrease in bone mass with increased susceptibility to bone fractures as a consequence. Osteoporosis causes a massive financial burden, particularly the treatment cost of fragility fractures and their future impact i.e work loss or disability. The fat-soluble vitamin K has two forms: K1 which be found in vegetables with green leaves, and K2 produced in the intestine by Lactobacillus bacteria and found mainly in fermented dairy. Recently, other functions of vitamin K2 have arisen. It is essential to bone physiology such as signaling, bone cell remodeling, and apoptosis. We performed a comprehensive search through the different databases for English-language sources to determine if vitamin K2 has a significant advance in bone health and/or fracture prevention in patients with osteoporosis. Also, how can vitamin K2 likely reduce the costs of osteoporosis-related fractures. literature reviews, unfortunately, showed that the preventive practice has a less served role in inpatient care. All findings point out that treatment with vitamin K2 can successfully prevent the incidence of osteoporosis-related fractures, and thus reduce its financial burden. Encouraging patients to consume a vitamin K2 enrichment diet also appears to be advantageous.

1.
A.
Consensus
,
Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis
.
Am. J. Med.
,
94
(
6
),
646
50
. (
1993
).
2.
A.
Svedbom
,
E.
Hernlund
,
M.
Ivergård
,
J.
Compston
,
C.
Cooper
,
J.
Stenmark
and
J. A.
Kanis
,
Osteoporosis in the European Union: a compendium of country-specific reports
.
Arch. Osteoporos.
8
(
1-2
),
137
. (
2013
).
3.
P.
Lakatos
,
Á.
Balogh
,
E.
Czerwinski
,
H. P.
Dimai
,
D.
Hans
,
G.
Holzer
and
I.
Takács
,
New considerations on the management of osteoporosis in Central and Eastern Europe (CEE): summary of the “3rd Summit on Osteoporosis— CEE
”,
November 2009, Budapest, Hungary. Archives of osteoporosis
,
6
(
1-2
),
1
12
. (
2011
).
4.
B. L.
Riggs
and
L. J.
Melton-Iii
,
The worldwide problem of osteoporosis: insights afforded by epidemiology
.
Bone
,
17
(
5
),
S505
S511
. (
1995
).
5.
P.
Lakatos
,
I.
Takács
,
I.
Marton
,
E.
Tóth
,
C.
Zoltan
,
Z.
Lang
and
M.
Intorcia
,
A retrospective longitudinal database study of persistence and compliance with treatment of osteoporosis in Hungary
.
Calcif. Tissue Int.
,
98
(
3
),
215
225
. (
2016
).
6.
J.
Iwamoto
,
Vitamin K2 therapy for postmenopausal osteoporosis
.
Nutrients
,
6
(
5
),
1971
1980
. (
2014
).
7.
T. D.
Falcone
,
S. S.
Kim
and
M. H.
Cortazzo
,
Vitamin K: fracture prevention and beyond. PM&R
,
3
,
S82
S87
. (
2011
).
8.
E. J.
Bruno
,
The prevalence of vitamin k deficiency/insufficiency, and recommendations for increased intake
.
Nutr. Food Sci.
,
4
(
1
),
1077
. (
2016
).
9.
R.
Flore
,
F. R.
Ponziani
,
T. A.
Di-Rienzo
,
M. A.
Zocco
,
A.
Flex
,
L.
Gerardino
and
E.
Chierici
,
Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis
.
Eur Rev Med Pharmacol Sci.
,
17
(
18
),
2433
2440
. (
2013
).
10.
Z. B.
Huang
,
S. L.
Wan
,
Y. J.
Lu
,
L.
Ning
,
C.
Liu
and
S. W.
Fan
,
Does vitamin K2 play a role in preventing and treating osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials
.
Osteoporos. Int.
,
26
(
3
),
1175
1186
. (
2015
).
11.
A.
Jayasena
,
N.
Atapattu
and
S.
Lekamwasam
,
Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review
.
Int. J. rheum. diseas.
,
18
(
3
),
287
293
. (
2015
).
12.
N.
Koitaya
,
M.
Sekiguchi
,
Y.
Tousen
,
Y.
Nishide
,
A.
Morita
,
J.
Yamauchi
and
F.
Watanabe
,
Low-dose vitamin K 2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women
.
J. Bone Miner. Metab
,
32
(
2
),
142
150
. (
2014
).
13.
G. K.
Schwalfenberg
,
Vitamins K1 and K2: the emerging group of vitamins required for human health
.
J Nutr Metab
,
6254836
. (
2017
).
14.
M.
Shiraki
,
Y.
Shiraki
,
C.
Aoki
and
M.
Miura
,
Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis
.
J. Bone Miner. Res
,
15
(
3
),
515
521
. (
2000
).
15.
M. A. B.
Naafs
,
Vitamin k2 deficiency: Is it real
.
Clin Dia and Cure Open A Open J
,
1
4
. (
2018
).
16.
N.
Sasaki
,
E.
Kusano
,
H.
Takahashi
,
Y.
Ando
,
K.
Yano
,
E.
Tsuda
and
Y.
Asano
,
Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG
).
J. Bone Miner. Metab.
,
23
(
1
),
41
47
. (
2005
).
17.
M.
Morishita
,
M.
Nagashima
,
K.
Wauke
,
H.
Takahashi
and
K.
Takenouchi
,
Osteoclast inhibitory effects of vitamin K2 alone or in combination with etidronate or risedronate in patients with rheumatoid arthritis: 2-year results
.
J. Rheumatol.
,
35
(
3
),
407
413
. (
2008
).
18.
N.
Inaba
,
T.
Sato
and
T.
Yamashita
,
Low-dose daily intake of vitamin K2 (menaquinone-7) improves osteocalcin γ-carboxylation: A double-blind, randomized controlled trial
.
J. Nutr. Sci. Vitaminol.
,
61
(
6
),
471
480
. (
2015
).
19.
A.
Capozzi
,
G.
Scambia
, and
S.
Lello
,
Calcium, itamin D, vitamin K2, and magnesium supplementation and skeletal health
.
Maturitas
,
140
,
55
63
. (
2020
).
20.
A.
Capozzi
,
G.
Scambia
,
S.
Migliaccio
, and
S.
Lello
,
Role of vitamin K2 in bone metabolism: a point of view and a short reappraisal of the literature
.
Gynecol. Endocrinol.
,
36
(
4
),
285
288
. (
2020
).
21.
J.
Iwamoto
,
Vitamin K2 therapy for postmenopausal osteoporosis
.
Nutrients
,
6
(
5
),
1971
1980
, (
2014
).
22.
A. R
Kemmak
,
A.
Rezapour
,
R.
Jahangiri
,
S.
Nikjoo
,
H.
Farabi
and
S.
Soleimanpour
,
Economic burden of osteoporosis in the world: A. systematic review
.
Med J Islam Repub Iran
,
34
,
154
. (
2020
).
23.
J.
Suttie
,
The importance of menaquinones in human nutrition
.
Annu. Rev. Nutr.
,
15
,
399
417
. (
1995
).
24.
B.
Walther
,
J. P
Karl
,
S. L
Booth
and
P.
Boyaval
,
Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements
.
Adv Nutr.
,
4
(
4
),
463
473
. (
2013
).
25.
S. J
Weng
,
D. Y
Yan
,
L.
Chen
,
Z. J
Xie
,
Z. Y
Wu
,
J. H.
Tang
and
V.
Boodhun
,
Combined treatment with vitamin K2 and PTH enhanced bone formation in ovariectomized rats and increased differentiation of osteoblast in vitro
.
Chem. Biol. Interact.
,
300
,
101
110
. (
2019
).
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