Microbial desalination cells (MDC)advanced from the technique of microbial fuel cells (MFC). Since its birth in 2009, MDCs have been used in applications. Including various configurations introduced by different researchers to solve some challenges in reactor operation. Only a few examples of applications include desalination of saltwater, brackish water, and groundwater remediation are all examples of desalination. Like any other technology, the performance and efficiency of this technology are governed by a variety of factors. The study also identifies and demonstrates the elements that have been compared in previous studies classified as technical topics over the years. Theoretically, indicating their importance in improving MDC is essential to expand its application in the future. The study also demonstrates the relationship between and well as how these elements contribute to the MDC reactor’s performance and efficiency, as well as its processing (operation)and future directions. Temperatures, PH, and hydraulic retention duration, This research looked at addition mode, external resistance, and starting concentration.

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