The intermolecular interactions of drug isoniazid (isonicotinic acid hydrazid), INH, with various electrolytic solutions like, aqueous solutions of tri-sodium and tri-potassium citrate (Na3Cit and K3Cit) have been analyzed at different temperatures T= (298.15-318.15) K and 0.1MPa pressure from the volumetric properties. The experimentally obtained density values have been used to compute, apparent molar volume, Vϕ, standard partial molar volume, Vϕ0, limiting molar expansivity, Eϕ0 and Hepler's constant. The positive values of partial molar volume and Hepler's constant signify the strong intermolecular interactions and the structure-making ability of drug isoniazid in the studied solutions respectively. The positive value of transfer volume of INH in the said solutions indicates the presence of ΔtrVϕ0 ionic-hydrophilic interaction among the constituents of the solutions.
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