Wound infection i.e., the colonization of wound by pathogenic organisms has become serious health problem. The wound bed provides a suitable environment to the organisms for their nourishment and proliferation at much faster rate. Although a number of methods are being used clinically to detect the wound infection, they are, sometime, not reliable due to the variable presentation profiles. Moreover, they are time consuming and also painful to the patients. Before wound infection becomes severe and spread further deeper in the body, their timely detection is very important in the wound management. In this context, development of theranostic smart wound dressings that allow the simultaneous monitoring and treatment of wound infections in response to wound environment have received great research interest of the scientific community. In this review article, we will review various such smart dressings and their theranostic applications in wound care.

1.
A.W.C.
Chua
,
Y.C.
Khoo
,
B.K.
Tan
,
K.C.
Tan
,
C.L.
Foo
, and
S.J.
Chong
,
Burn. Trauma.
4
,
1
14
(
2016
).
2.
S. O.
Callaghan
,
P.
Galvin
,
C. O.
Mahony
,
Z.
Moore
, and
R.
Derwin
,
J. Wound Care.
29
,
394
406
(
2020
).
3.
S.
Guo
and
L.A.
DiPietro
,
J. Dent. Res.
89
,
219
229
(
2010
).
4.
G.D.
Venkatasubbu
,
S.
Nagamuthu
,
T.
Anusuya
,
J.
Kumar
,
R.
Chelliah
,
S.R.
Ramakrishnan
,
U.
Antony
,
I.
Khan
, and
D.-H.
Oh
,
Mater. Res. Express.
5
,
0
30
(
2018
).
5.
D.
Prema
,
J.
Prakash
,
S.
Vignesh
,
P.
Veluchamy
,
C.
Ramachandran
,
D.B.
Samal
,
D.-H.
Oh
,
S.
Sahabudeen
, and
G.D.
Venkatasubbu
,
Appl. Nanosci.
10
,
827
849
(
2020
).
6.
G.
Hosgood
,
Vet. Clin. North Anim.
36
,
667
685
(
2006
).
7.
R.S.
Kirsner
and
W.H.
Eaglstein
,
Dermatol. Clin.
11
,
629
640
(
1993
).
8.
K.M.
Zepon
,
M.M.
Martins
,
M.S.
Marques
,
J.M.
Heckler
,
F. Dal Pont
Morisso
,
M.G.
Moreira
,
A.L.
Ziulkoski
, and
L.A.
Kanis
,
Carbohydr. Polym.
206
,
362
370
(
2019
).
9.
R. N. F. Moreira
Filho
,
N. F.
Vasconcelos
,
F. K.
Andrade
,
M. de F.
Rosa
, and
R.S.
Vieira
,
Colloids Surf. B.
194
,
111222
(
2020
).
10.
B.
Qiao
,
Q.
Pang
,
P.
Yuan
,
Y.
Luo
, and
L.
Ma
,
Biomater. Sci.
8
,
1649
1657
(
2020
).
11.
O.
Castaño
,
S.
Pérez-Amodio
,
C.
Navarro-Requena
,
M.Á.
Mateos-Timoneda
, and
E.
Engel
,
Adv. Drug Deliv. Rev.
129
,
95
117
(
2018
).
12.
J.
Zhou
,
D.
Yao
,
Z.
Qian
,
S.
Hou
,
L.
Li
,
A.T.A.
Jenkins
, and
Y.
Fan
,
Biomaterials.
161
,
11
23
(
2018
).
13.
J.D.
Oliver
,
Epidemiol. Infect.
133
,
383
391
(
2005
).
14.
A.
DeCherney
and
G.
Berkowitz
,
N. Engl. J. Med.
306
,
424
426
(
1982
).
15.
A.
von Graevenitz
,
Annu. Rev. Microbiol.
31
,
447
471
(
1977
).
16.
W.M.
Chan
,
D.T.L.
Liu
,
C.K.M.
Chan
,
K.K.L.
Chong
, and
D.S.C.
Lam
,
Clin. Infect. Dis.
37
,
31
34
(
2003
).
17.
A.
Mellmann
,
M.
Bielaszewska
,
L.B.
Zimmerhackl
,
R.
Prager
,
D.
Harmsen
,
H.
Tschäpe
, and
H.
Karch
,
Clin. Infect. Dis.
41
,
785
792
(
2005
).
18.
D.
Simões
,
S.P.
Miguel
,
M.P.
Ribeiro
,
P.
Coutinho
,
A.G.
Mendonça
, and
I.J.
Correia
,
Eur. J. Pharm. Biopharm.
127
,
130
141
(
2018
).
19.
M.
Goudarzi
,
Z.
Tayebi
,
M.
Dadashi
,
M.
Miri
,
A.
Amirpour
, and
M.
Fazeli
,
Gene Rep.
19
,
100603
(
2020
).
20.
H.
Boucher
,
L.G.
Miller
, and
R.R.
Razonable
,
Clin. Infect. Dis.
51
,
183
197
(
2010
).
21.
C.
Xu
,
O.U.
Akakuru
,
X.
Ma
,
J.
Zheng
,
J.
Zheng
, and
A.
Wu
,
Bioconjug. Chem.
31
,
1708
1723
(
2020
).
22.
E.
Gaworzewska
and
G.
Colman
,
Epidemiol. Infect.
100
,
257
269
(
1988
).
23.
X.
Chen
,
F.
Wo
,
Y.
Jin
,
J.
Tan
,
Y.
Lai
, and
J.
Wu
,
ACS Nano.
11
,
7938
7949
(
2017
).
24.
M.
Schäfer
and
S.
Werner
,
Pharmacol. Res.
58
,
165
171
(
2008
).
25.
A.
Soneja
,
M.
Drews
, and
T.
Malinski
,
Pharmacol. Rep.
57
,
108
119
(
2005
).
26.
B.
Mirani
,
E.
Pagan
,
B.
Currie
,
M.A.
Siddiqui
,
R.
Hosseinzadeh
,
P.
Mostafalu
,
Y.S.
Zhang
,
A.
Ghahary
, and
M.
Akbari
,
Adv. Healthc. Mater.
6
,
1
15
(
2017
).
27.
T.
Maral
,
H.
Borman
,
H.
Arslan
,
B.
Demirhan
,
G.
Akinbingol
, and
M.
Haberal
,
Burns.
25
,
625
635
(
1999
).
28.
P.H.
Corkhill
,
C.J.
Hamilton
,
and B.J.
Tighe
,
Biomaterials.
10
,
3
10
(
1989
).
29.
R.G.C.
Teepe
,
E.J.
Koebrugge
,
C.W.G.M.
Lowik
,
P.L.C.
Petit
,
R.W.
Bosboom
,
I.M.
Twiss
,
H.
Boxma
,
B.J.
Vermeer
, and
M.
Ponec
,
J. Trauma Inj. Infect. Crit. Care.
35
,
8
19
(
1993
).
30.
D.R.
Griffin
,
W.M.
Weaver
,
P.O.
Scumpia
,
D.
Di Carlo
, and
T.
Segura
,
Nat. Mater.
14
,
737
744
(
2015
).
31.
X.
Wang
,
J.
Ge
,
E.E.
Tredget
, and
Y.
Wu
,
Nat. Protoc.
8
,
302
309
(
2013
).
32.
T.R.
Ray
,
J.
Choi
,
A.J.
Bandodkar
,
S.
Krishnan
,
P.
Gutruf
,
L.
Tian
,
R.
Ghaffari
, and
J.A.
Rogers
,
Chem. Rev.
119
,
5461
5533
(
2019
).
33.
W.
Honda
,
S.
Harada
,
T.
Arie
,
S.
Akita
, and
K.
Takei
,
Adv. Funct. Mater.
24
,
3299
3304
(
2014
).
34.
H.
Jin
,
Y. S.
Abu-raya
, and
H.
Haick
,
Adv. Healthc. Mater.
6
,
1700024
(
2017
).
35.
Q.
Pang
,
D.
Lou
,
S.
Li
,
G.
Wang
,
B.
Qiao
,
S.
Dong
,
L.
Ma
,
C.
Gao
, and
Z.
Wu
,
Adv. Sci.
7
,
1902673
(
2020
).
36.
H.
Singh
,
W.
Li
,
M.R.
Kazemian
,
R.
Yang
,
C.
Yang
,
S.
Logsetty
, and
S.
Liu
,
ACS Appl. Bio Mater.
2
,
2028
2036
(
2019
).
37.
J.F.
Shaw
,
C.H.
Chang
, and
Y.J.
Wang
,
Biotechnol. Lett.
11
,
779
784
(
1989
).
38.
S.
Benjamin
and
A.
Pandey
,
Braz Arch Biol Technol.
44
,
213
221
(
2001
).
39.
Q.
Zhou
,
J.
Wang
,
Y.
Liang
,
H.
Yang
,
Q.
Li
, and
Q.
Li
,
Chem. Nano. Mat.
6
,
516
523
(
2020
).
40.
P.
Mostafalu
,
A.
Tamayol
,
R.
Rahimi
,
M.
Ochoa
,
A.
Khalilpour
,
G.
Kiaee
,
I.K.
Yazdi
,
S.
Bagherifard
,
M.R.
Dokmeci
,
B.
Ziaie
, and
S.R.
Sonkusale
,
A. Khademhosseini, Small.
14
,
1
9
(
2018
).
41.
S.
Bagherifard
,
A.
Tamayol
,
P.
Mostafalu
,
M.
Akbari
,
M.
Comotto
,
N.
Annabi
,
M.
Ghaderi
,
S.
Sonkusale
,
M.R.
Dokmeci
, and
A.
Khademhosseini
,
Adv. Healthc. Mater.
5
,
175
184
(
2016
).
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