In South Sumatera, the increase in COVID-19 occurred after three weeks of confirmed cases in Indonesia. The community’s knowledge, attitudes, and behavior toward COVID-19 are an integral part of the fight against COVID-19. Community compliance with preventive behavior against COVID-19 can reduce transmission rates. This study aims to describe COVID-19 prevention behavior using masks, washing hands, and social distancing in Palembang. Crossectional study methods were conducted on 602 respondents using questionnaires collected using google forms. To see an overview of preventive behavior and the factors that affect it, use the chi-square test. Most of the respondents already have good knowledge and attitude about the prevention of COVID-19. Respondents who used masks as much as 95.2%, kept their distance (89.9%) and washed their hands (92.4%). Some variables such as age groups, type of occupation, education level, level of knowledge, and positive attitude of respondents towards COVID-19 are related to the behavior of wearing a mask. Furthermore, the variables related to social distancing behavior are respondents’ knowledge and attitude, while those associated with handwashing behavior are education and knowledge levels. The use of masks is the primary choice in preventing COVID-19. The older the age, the more obedient the respondents using masks and washing their hands, but not social distancing.

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