Dementia is a chronic or progressive syndrome characterized by impaired cognitive capacity from Alzheimer’s disease in which the expression of the Caspase-9 and Calm1 genes is one of the genes that play a role in this disease. This study aims to see gene expression of Caspase-9 and Calm1 in rat models of Alzheimer’s disease after the addition of Mesenchymal Stem Cell Wharton Jelly (MSC-WJ). The treatment group consisted of a control, AlCl3, MSC-WJ, and a combination of AlCl3 and MSC-WJ. All treatment groups were tested using the Realtime PCR (RT-PCR) method. All experimental groups were analyzed using the one-way ANOVA test using SPSS. If the p-value <0.05, then this value is considered significant. The results showed that the giving of MSC-WJ had a significant effect on the expression of the Caspase-9 gene with a p-value of 0.044 but didn’t have a significant on the expression of the Calm1 gene expression with a p-value of 0.761. The conclusion of this study showed that the administration of MSC-WJ affects the gene expression of Caspase-9 a gene that plays a role in the apoptosis of cells but has no effect on the gene expression Calm1 as a gene involved in calcium signaling.

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