SARS-Cov-2 or 2019-nCoV (more commonly known as COVID-19 or simply, the novel coronavirus) belongs to the family of coronaviridae and it was first re-ported in late 2019 in China and quickly became a global pandemic because of its high rate of infectibility and transmission. To date, there is no known and effec-tive medicine for it and hence it continues to remain a global threat and a major disruption to the normal functioning of the world. Efforts to find a prevention or cure against the infection of the virus are in progress and one way of dealing with it is the inactivation of the surface proteins of the virus. Like other members of the coronaviridae family, SARS-Cov-2 has four structural proteins among which, the spike proteins (S-proteins) found on its surface are used to bind and fuse with a host cell. If these S-proteins can be inactivated using any external agents, the infectivity of the virus can be potentially decreased. Here we discuss the recent advancements in the theoretical and experimental research on the usage of known compounds and methods that have shown potential to inactivate the S-proteins of the virus. We believe, this indicative review will be helpful to direct efforts towards finding a therapeutic/preventive intervention against the SARS-Cov-2 virus.

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