Formulation and evaluation of physical properties of katuk (Sauropus androgynus L merr) leaf extract tablets using wet granulation method as antioxidant and antibacterial

Katuk plant is a plant that is often found in the community, this plant contains compounds containing alcaloids, triterpenoids, saponins, tannins, polyphenols, glycosides and flavonoids. This katuk plant has considerable benefits, namely to increase breast milk, overcome constipation, lose weight, anti hypertension, anti hyperlipidemia, constipation, and can treat infections. This plant has not been widely used by the community in the field of medicine as an antioxidant and antibacterial, so this study aims to make the best formulation of katuk leaf extract more widely used by the community as an antioxidant and antibacterial. This type of research is purely experimental. The method used in the manufacture of tablets is wet granulation, tablet formulations are made with various concentrations of PVP 5% (F1), 7.5% (F2), and 10% (F3). The evaluation of lozenges included organoleptic test, weight uniformity test, friability test which was analyzed descriptively and flow time test, angle of repose and tablet hardness test which were analyzed using one-way ANOVA. The result of this research is that the best formulation of leaf extract tablets is formula 3 which contains PVP with a concentration of 10%. Katuk leaf tablets are proven to be effective as antioxidants that can counteract free radicals with an IC50 value of 106,91 µg/mL which is a moderate antioxidant. Katuk leaf extract tablet which has an inhibitory power against Staphylococcus aureus is the third formula with an average inhibition zone of 31.5 mm.