Optimization of molecularly imprinted polymers (MIPs) membrane absorption for uric acid

Molecularly Imprinted Polymers (MIPs) have been synthesized and can be used as uric acid absorbent in samples. MIPs can absorb uric acid because MIPs have cavities were formed by the removal of uric acid. The purpose of this research was to determine the synthesis, characteristics of MIPs membrane, and MIPs absorption for uric acid at optimum conditions. The method used for the synthesis of MIPs membrane is the photopolymerization method using Ultra-Violet light. Determination of uric acid levels in solution was analyzed by spectrophotometer UV-Vis and in blood by Easy Touch. Based on the research obtained a transparent uric acid MIPs membrane. The result of the FTIR spectrum analysis showed that the infrared spectra characterization of the MIPs-extraction membrane did not find N-H absorption peak, while in the MIPs re-extraction there was an absorption peak in the 910-665. The N-H group is the functional group of uric acid. Based on absorption under optimum conditions the number of MIPs membrane used was 0.08 grams with contact time of 24 hours and pH of 7.57 uric acid solution obtained the efficiency of MIPs absorption in solution was 72.6%, while the efficiency of MIPs absorption of uric acid in the blood was 24.6 %. The result of this study indicate that the MIPs membrane can absorb uric acid both in solution and in blood.