Microbial infections cause many diseases. Synthetic antibiotics can treat infection, but their use in the long term causes microbial resistance. The nanoparticle preparation is well known to increase the effectiveness of a natural material as an antimicrobial. This research aims to determine the antimicrobial activity of C. mangga nanoparticles in vitro. Manufacture of nanoparticles using the ionic gelation method. Inhibition zone test for C. mangga nanoparticles with a concentration of 2.5% using the Kirby-Bauer method. Tests for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using the microdilution method with variations in concentrations of 2.5%, 1.25%, 0.625%, 0.313%, 0.156% and 0.078%. The zone of inhibition of C. mangga nanoparticles against E. coli was 11.46±1.07 mm (strong), against C. albicans 11.04±1.26 mm (strong), and S. aureus 6.40±1.77 mm (moderate). The MIC and MBC test values of E. coli were 1.25% and 2.5%, while S. aureus was 0.625% and 1.25%, and C. albicans was 0.313% and 0.625%. C. mangga nanoparticles have good potential as natural antimicrobial agents against bacteria and fungi.

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