The effect of TEOS precursor and CTAB addition in the synthesis of magnetic mesoporous silica nanoparticles for drug delivery Available to Purchase

Nanoscale drug delivery systems have been found to increase drug loading efficiency and avoid the body’s immune response. In this research, magnetic mesoporous nanosilica was developed as a drug carrier by utilizing Kulon Progo iron sand’s natural resources as the material. Magnetic mesoporous nanosilica was synthesized by the coprecipitation method using NH₄OH as the precipitant. The synthesis was carried out in three stages to see the effect of adding silica and surfactant at each stage. The first stage was Fe₃O₄ synthesis from iron sand. The second stage included the synthesis of Fe₃O₄@SiO₂ by adding Tetraethyl Orthosilicate (TEOS) as the silica precursor. The last stage was the synthesis of Fe₃O₄@SiO₂−CTAB, in which Cetyltrimethylammonium Bromide (CTAB) was the surfactant used. Each of the materials synthesized was characterized using X-Ray Diffraction (XRD) and Energy Dispersive X-Ray (EDX). The crystalline size calculation results using XRD data show that the particles are in nano size, the particle size of Fe₃O₄@SiO₂−CTAB nanoparticles obtained 6.77 nm. Simultaneously, the % crystallinity also shows better crystal quality results after the addition of the two compounds. This influence can also be seen from the EDX analysis, where Fe decreases and new compositions, namely Si and Br, are present.