The Covid-19 pandemic has affected the way students learn from face-to-face to online learning. This condition is a challenge for educators to provide online teaching materials. Teaching materials developed to facilitate students to learn independently. The characteristics of the teaching materials developed give students the freedom to learn and facilitate the development of their abilities and skills. This study aimed to analyze the effectiveness of blended learning-based laboratory inquiry teaching materials in improving students' self-regulated learning in terms of gender. This type of research is a quasi-experimental research. The test subjects in this study were class XI in one of the public high schools in Mataram City, which consisted of two classes, namely the experimental class and the control class, which consisted of 67 students. There are 34 male students and 33 female students. The data collection technique used a self-regulated learning questionnaire instrument. The instrument refers to seven indicators of self-regulated learning. Data analysis was carried out using N-gain and T-test. The results showed that blended learning-based laboratory inquiry teaching materials could increase students' self-regulated learning. Based on the results of the T test, there was a significant difference between the control class and the experimental class. The third self-regulated learning indicator, namely goal setting and planning, got the highest increase compared to other indicators. The second indicator, namely organization and information, obtained the lowest increase compared to other indicators. Self-regulated learning of male students is higher than female students. With the availability of online class media in the blended learning learning model that can be accessed anytime and anywhere by students, it can increase the readiness of students themselves before face-to-face learning in class takes place. Student activity also increases because by providing material earlier through media uploaded to online classes it will stimulate students to look for other material that is still related and be more active in asking things they do not understand.

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