Since the beginning of the pandemic, several studies have revealed a link between the ABO blood group and COVID-19. The objective of this study is to determine the association between the ABO blood group and COVID-19 susceptibility in Baghdad city, Iraq. We compared ABO blood group distributions in 414 (269 female, 145 male) COVID-19 patients with 56 (29 female, 27 male) healthy controls to see if there was any link between COVID-19 disease and blood group during February to July 2020. Their ages ranged from less than 10 to more than 70 years. We found that females with blood group O and Rh (positive) were associated with an increased risk of infection, while blood group AB and Rh (negative) were associated with a decreased risk. Cases aged 20-29 were the most infected with COVID-19 among other age groups. We think this is the first study that found the relationship between Covid-19 and O blood type in our country and the only one in the world literature.

1.
Komal
A
,
Noreen
M
,
Akhtar
J
,
Imran
M
,
Jamal
M
,
Atif
M
, et al
Analyses of ABO blood groups with susceptibility and symptomatic variations of COVID-19 infection, a questionnaire-based survey
.
Apmis.
2021
;
129
(
10
):
579
86
.
2.
Dzik
S
,
Eliason
K
,
Morris
EB
,
Kaufman
RM
,
North
CM
.
COVID-19 and ABO blood groups
.
Transfusion.
2020
;
60
(
8
):
1883
4
.
3.
Abegaz
SB
.
Human ABO Blood Groups and Their Associations with Different Diseases
.
Biomed Res Int.
2021
;2021.
4.
Lindesmith
L
,
Moe
C
,
Marionneau
S
,
Ruvoen
N
,
Jiang
X
,
Lindblad
L
, et al
Human susceptibility and resistance to Norwalk virus infection
.
Nat Med
[Internet].
2003
;
9
(
5
):
548
53
. Available from:
5.
Batool
Z
,
Durrani
SH
,
Tariq
S.
Association Of Abo And Rh Blood Group Types To Hepatitis B, Hepatitis C, Hiv And Syphilis Infection, A Five Year’ Experience In Healthy Blood Donors In A Tertiary Care Hospital
.
J Ayub Med Coll Abbottabad.
2017
;
29
(
1
):
90
2
.
6.
Cooling
L.
Blood groups in infection and host susceptibility
.
Clin Microbiol Rev.
2015
;
28
(
3
):
801
70
.
7.
Fan
Q
,
Zhang
W
,
Li
B
,
Li
DJ
,
Zhang
J
,
Zhao
F.
Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan
.
Front Cell Infect Microbiol.
2020
;10(July):
1
7
.
8.
Kim
Y
,
Latz
CA
,
DeCarlo
CS
,
Lee
S
,
Png
CYM
,
Kibrik
P
, et al
Relationship between blood type and outcomes following COVID-19 infection
.
Semin Vasc Surg
[Internet].
2021
; Available from: https://www.sciencedirect.com/science/article/pii/S0895796721000405
9.
Aljanobi
GA
,
Alhajjaj
AH
,
Alkhabbaz
FL
,
Al-Jishi
JM
.
The Relationship between ABO Blood Group Type and the COVID-19 Susceptibility in Qatif Central Hospital, Eastern Province, Saudi Arabia: A Retrospective Cohort Study
.
Open J Intern Med.
2020
;
10
(
02
):
232
8
.
10.
Mgh
B
,
Affairs
N.
COVID-19 and Blood Type blood type and severity of COVID-19
.
2021
;
1
5
.
11.
Zietz
M
,
Zucker
J
,
Tatonetti
NP
.
Associations between blood type and COVID-19 infection, intubation, and death
.
Nat Commun
[Internet].
2020
;
11
(
1
):
1
6
. Available from:
12.
Kenneth Weir
E
,
Thenappan
T
,
Bhargava
M
,
Chen
Y.
Does Vitamin D deficiency increase the severity of COVID-19? Clin Med J R Coll Physicians London.
2020
;
20
(
4
):
E107
8
.
13.
Dahlén
T
,
Clements
M
,
Zhao
J
,
Olsson
ML
,
Edgren
G.
An agnostic study of associations between abo and rhd blood group and phenome-wide disease risk
.
Elife.
2021
;
10
:
1
12
.
14.
Zhao
J
,
Yang
Y
,
Huang
H
,
Li
D
,
Gu
D
,
Lu
X
, et al
Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility
.
Clin Infect Dis.
2021
;
73
(
2
):
328
31
.
15.
DL
S
,
ED
M
, M
R
,
E T
, C
O
,
L E
, et al
Severe life-threatening cholera associated with blood group O in Peru: implications for the Latin American epidemic
.
J Infect Dis
[Internet].
1994
[cited 2021 Sep 25];
170
(
2
):
468
72
. Available from: https://pubmed.ncbi.nlm.nih.gov/8035040/
16.
Jassim
WE
.
Association of ABO blood group in Iraqis with hypercholesterolaemia, hypertension and diabetes mellitus
.
East Mediterr Heal J.
2012
;
18
(
8
):
888
91
.
17.
AM
A
,
CC
B
,
DM
W.
Increased inflammatory responses of persons of blood group O to Helicobacter pylori
.
J Infect Dis
[Internet].
2000
[cited 2021 Sep 25];
181
(
4
):
1364
9
. Available from: https://pubmed.ncbi.nlm.nih.gov/10753728/
18.
Goel
R
,
Bloch
EM
,
Pirenne
F
,
Al-Riyami
AZ
,
Crowe
E
,
Dau
L
, et al
ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group
.
Vox Sang.
2021
;
116
(
8
):
849
61
.
19.
Alubadi
A.
Genetic Analysis of ABO and Rh ( D ) Blood Groups in Arab Baghdadi Ethnic Groups
.
Al-Mustansiriyah J Sci.
2013
;
24
(
1
):
37
46
.
20.
Alsjanabi
A.
Gene frequency of blood groups in the middle Euphrates region
.
J kerbala Univ.
2005
;(
11
).
21.
Jaff
.
ABO and rhesus blood group distribution in Kurds
.
J Blood Med.
2010
;
143
.
22.
Saleh
SM
,
Abood AS. ABO and Rh (D) blood groups’ distribution and gene frequencies in North Baghdad population–Iraq
.
Int J Sci Eng Res.
2016
;
7
(August):
2
4
.
23.
Samra
S
,
Habeb
M
,
Nafae
R.
ABO groups can play a role in susceptibility and severity of COVID-19
.
Egypt J Bronchol.
2021
;
15
(
1
).
24.
Hultström
M
,
Persson
B
,
Eriksson
O
,
Lipcsey
M
,
Frithiof
R
,
Nilsson
B.
Blood type A associates with critical COVID-19 and death in a Swedish cohort
.
Crit Care.
2020
;
24
(
1
):
1
2
.
25.
Barnkob
MB
,
Pottegård
A
,
Støvring
H
,
Haunstrup
TM
,
Homburg
K
,
Larsen
R
, et al
Reduced prevalence of SARS-CoV-2 infection in ABO blood group O
.
Blood Adv.
2020
;
4
(
20
):
4990
3
.
26.
Ad’hiah
AH
,
Allami
RH
,
Mohsin
RH
,
Abdullah
MH
,
AL-Sa’ady
AJR
,
Alsudani
MY
.
Evaluating of the association between ABO blood groups and coronavirus disease 2019 (COVID-19) in Iraqi patients
. Vol.
21
,
Egyptian Journal of Medical Human Genetics.
2020
.
27.
Esref
A
,
Solmaz
I
,
Akkoc
H
,
Donmezdil
S
,
Karahan
Z
,
Safak
K
, et al
Association between the Rh blood group and the Covid-19 susceptibility
.
Int J Hematol Oncol.
2020
;
31
(
2
):
81
6
.
28.
Almadhi
MA
,
Abdulrahman
A
,
Alawadhi
A
,
Rabaan
AA
,
Atkin
S
,
AlQahtani
M.
The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes
.
Sci Rep
[Internet].
2021
;
11
(
1
):
19
23
. Available from:
29.
Wu
BB
,
Gu
DZ
,
Yu
JN
,
Yang
J
,
Wang-Qin
S.
Association between ABO blood groups and COVID-19 infection, severity and demise: A systematic review and meta-analysis
.
Infect Genet Evol.
2020
Oct 1;
84
:
104485
.
30.
Latz
CA
,
DeCarlo
C
,
Boitano
L
,
Png
CYM
,
Patell
R
,
Conrad
MF
, et al
Blood type and outcomes in patients with COVID-19
.
Ann Hematol.
2020
;
99
(
9
):
2113
8
.
31.
Kumar
G
,
Nanchal
R
,
Hererra
M
,
Sakhuja
A
,
Patel
D
,
Meersman
M
, et al
Does ABO Blood Groups Affect Outcomes in Hospitalized COVID-19 Patients?
J Hematol
[Internet].
2021
;
10
(
3
):
98
105
. Available from:
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