Biologically active maleimide compounds (M1-M6) have been synthesized via imidization of 3-amino benzoic acid with maleic anhydride in glacial acetic acid. Six different drugs (Silver-Sulfadiazine, Cefotaxime, Ciprofloxacin, Amoxicillin, Cephalexin and Ceftriaxone) were binding with maleimide derivative in presence of triethyl amine. The maleimide-drug derivatives (M1-M6) were characterized by FT–IR and 1HNMR and screened for their antibacterial activity against pathogenic strains of Escherichia coli (ATCC 8739) and Staphylococcus aurous (ATCC25923) at concentration of 0.5 mg/mL of each compounds using corresponding drugs as standards by disk-diffusion method. The results show good synergistic effect as inhibition zone increased for M2 and M5 against (S. aurous) in comparison with Silver-Sulfadiazine and Cephalexin as positive control. Whereas, M1, M3, M5 and M6 derivatives showed higher synergistic effect against (E. coli) than Silver-Sulfadiazine, Ciprofloxacin, Cephalexin, ceftriaxone.

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