This study aims to (1) Develop of health biotechnology e-module through Kvisoft Flipbook Maker which enhance the analytical thinking ability of learners (2) Knowing the response of teachers and learners to the development of health biotechnology e-module through Kvisoft Flipbook Maker that enhance students' analytical thinking skills. This research is included in the type of Research and Development research (RnD). The research model used is 4D but adapted into 3D (Define, Design and Development). The study was conducted at SMA Negeri 2 Surakarta on April 5, 2021. The 3rd graders of high school are the subject. The validation stage is performed by 1 media expert, 1 material expert and 1 learning expert. Instruments used in the study include needs analysis questionnaires, teacher response questionnaires, student response questionnaires, and test questions (pretest and posttest). Data retrieval techniques are carried out by sharing questionnaires of teachers and students' responses after learning. Data analysis techniques using qualitative and quantitative analysis. The results of the research conducted was a e-modules health biotechnology which can be accessed by smartphones and PC. E-module has been validated by the material expert validator with a score of 81.5 % (feasible), media experts with a score of 88.63 % (very feasible), and learning experts with an RPP score of 88.42 % (very feasible) and a test question score of 76 % (feasible). The teacher's response showed a score of 92.10 % (very feasible), while for student's response score can be known through T paired test. The test results showed that there was an improvement in students' analytical thinking ability through T paired test sig. 0.00<0.05, so it can be concluded that the health biotechnology e-module media through Kvisoft Flipbook Maker is able to enhance students' analytical thinking skills.

Topics
Data storage and retrieval, Students, Educational institutions, Learning and learning models, Educational assessment, Teaching, Biotechnology
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