Immune system is one of topic in biology which considered as problematic by students and challenging for teachers in conveys them in online learning. Gaming learning is one alternative to ease and engage the students and teachers in understanding the immune system. To bring gaming learning of immune system as an intervention in teaching and learning, a prerequisites analysis needs to be run to understand the existing practices of teaching and learning on immune system, and the readiness of teachers and students on the intervention of gaming learning. The aim of this study was to determine the learning process of the immune system during the Covid-19 pandemic and explore teacher and students' perceptions and readiness to use the gaming learning. The basic interpretative studies were conducted by collecting data through interview to four biology teachers, and questionnaire to the students (N=387). The data was analysed descriptively. It is found that: 1) The online learning caused boredness due to the monotonous tools used by the teacher, 3) The teachers perceive that gaming learning can help students learn the concept of the immune system, eventhough they have lack of understanding and experiences on adopting the gaming learning. 4) The students are ready to accept gaming learning and have adequate facilities to support the learning, and . 5) The adventure game is the type of game that students like the most. The findings should be considered in designing the gaming learning on immune system in the future research.
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