Propolis is a resinous substance extracted from the plants around the honeycomb, which can be used to construct, adjust and protect the bee colony. Propolis has been known to have various benefits as traditional medicine. It contains flavonoid, caffeic acid phenethyl ester, cinnamic acid, and artepillin C, which may play a role in the immune system and promote lymphocyte proliferation. Thus, it is referred to as an immunomodulator. However, the use of liquid propolis as an active substance faces solubility problems. Propolis powder is present to overcome the limitations of the formulation of pharmaceutical preparations and can be developed as a traditional medicine with immunomodulatory activity. The purpose of this investigation was to see if propolis powder has any immunomodulatory effects using the phagocytosis macrophages method. The RAW 264.7 macrophage cell lines which had been cultured, were used in this study. Propolis samples at dosages of 100 g/ml, 50 g/ml, 25 g/ml, 12.5 g/ml, and 6.25 g/ml were used to determine the percentage of activity in RAW 264.7 macrophage cells. According to the results of this study, giving propolis powder at a dosage of 12.5 g/ml resulted in the highest macrophage capacity for phagocytosis (31±3%). In other words, propolis powder at that concentration had the greatest stimulating impact or increased phagocytosis activity the most.
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16 August 2022
THE 6TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 6th International Symposium of Biomedical Engineering (ISBE) 2021
7–8 July 2021
Depok, Indonesia
Research Article|
August 16 2022
Immunomodulatory activity of propolis powder from Tetragonula sapiens on macrophage function
Nurul Azizah;
Nurul Azizah
a)
1
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia
, Kampus UI Depok, West Java 16424 Indonesia
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Diah Kartika Pratami;
Diah Kartika Pratami
c)
2
Faculty of Pharmacy, Pancasila University, South Jakarta
, Jakarta 12640 Indonesia
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Heri Hermansyah;
Heri Hermansyah
d)
1
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia
, Kampus UI Depok, West Java 16424 Indonesia
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Siti Farida;
Siti Farida
e)
3
Faculty of Medicine, Universitas Indonesia
, Kampus UI Depok, West Java 16424 Indonesia
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Muhamad Sahlan
Muhamad Sahlan
b)
1
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia
, Kampus UI Depok, West Java 16424 Indonesia
b)Corresponding author: [email protected]
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b)Corresponding author: [email protected]
AIP Conf. Proc. 2537, 040007 (2022)
Citation
Nurul Azizah, Diah Kartika Pratami, Heri Hermansyah, Siti Farida, Muhamad Sahlan; Immunomodulatory activity of propolis powder from Tetragonula sapiens on macrophage function. AIP Conf. Proc. 16 August 2022; 2537 (1): 040007. https://doi.org/10.1063/5.0098749
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