Synthesis of 4-(3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol as antibacterial agent was performed by cycloaddition reaction. These compound was performed by refluxing the chalcone with phenylhydrazine in acidic condition for 4 h. The structure of the synthesized compound was confirmed by FTIR and 1H-NMR spectrometers. The pyrazoline was screened for antibacterial activity by agar well-diffusion against Staphylococcus aureus, Bacillus cereus, Bacillus subtillis, Escherichia coli and Shigella flexnerri. The pyrazoline was found to exhibits an antibacterial activity and its zone of inhibition/concentration against Staphylococcus aureus (4.75/100), Bacillus cereus (2.50/500), Bacillus subtillis (4.50/300), Escherichia coli (4.75/500) and Shigella flexnerri (3.75/300). The result showed that the pyrazoline which were subtituted with chloro, hydoxy, and methoxy, was able to inhibit the growth of the tested pathogenic bacteria.
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9 October 2023
THE 3RD INTERNATIONAL CONFERENCE ON COMPUTER, SCIENCE, ENGINEERING AND TECHNOLOGY (ICComSET 2020)
22 December 2020
Tasikmalaya, Indonesia
Research Article|
October 09 2023
In vitro antibacterial activity test of 4-(3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol
Estin Nofiyanti;
Estin Nofiyanti
a)
1
Environmental Engineering Department, Universitas Muhammadiyah Tasikmalaya
, 46196, Indonesia
a)Corresponding author: estin.nofi@umtas.ac.id
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Noer Laelly Btag;
Noer Laelly Btag
2
Electronical Engineering Department, Universitas Muhammadiyah Tasikmalaya
, 46196, Indonesia
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Novi Nurjanah;
Novi Nurjanah
1
Environmental Engineering Department, Universitas Muhammadiyah Tasikmalaya
, 46196, Indonesia
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Nurcholis Salman;
Nurcholis Salman
1
Environmental Engineering Department, Universitas Muhammadiyah Tasikmalaya
, 46196, Indonesia
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Tutik Dwi Wahyuningsih
Tutik Dwi Wahyuningsih
3
Chemical Organic Laboratory, Chemistry Department, Universitas Gadjah Mada
, Yogyakart, 55281, Indonesia
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a)Corresponding author: estin.nofi@umtas.ac.id
AIP Conf. Proc. 2510, 050001 (2023)
Citation
Estin Nofiyanti, Noer Laelly Btag, Novi Nurjanah, Nurcholis Salman, Tutik Dwi Wahyuningsih; In vitro antibacterial activity test of 4-(3-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol. AIP Conf. Proc. 9 October 2023; 2510 (1): 050001. https://doi.org/10.1063/5.0128440
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