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Research Article| December 05 2022

Bioassay guided isolation of artoindonesianin C with antidiabetic activity from Artocarpus elasticus Reinw. ex. Blume bark

Sofa Fajriah;

Sofa Fajriah ^a)

1

Research Center for Chemistry, National Research and Innovation Agency Republic of Indonesia

Kawasan PUSPIPTEK Serpong, Kota Tangerang Selatan, Banten,

Indonesia

^a)Corresponding author: [email protected]; [email protected]

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Hariyanti;

Hariyanti

2

Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. DR. HAMKA

Jl. Limau II, Kebayoran Baru, Jakarta Selatan, Jakarta,

Indonesia

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Angie Elviani;

Angie Elviani

2

Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. DR. HAMKA

Jl. Limau II, Kebayoran Baru, Jakarta Selatan, Jakarta,

Indonesia

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Mariyana Sanusi;

Mariyana Sanusi

2

Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. DR. HAMKA

Jl. Limau II, Kebayoran Baru, Jakarta Selatan, Jakarta,

Indonesia

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Megawati

Megawati

1

Research Center for Chemistry, National Research and Innovation Agency Republic of Indonesia

Kawasan PUSPIPTEK Serpong, Kota Tangerang Selatan, Banten,

Indonesia

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Author & Article Information

Sofa Fajriah ^1,a)

,

Hariyanti ²

,

Angie Elviani ²

,

Mariyana Sanusi ²

,

Megawati ¹

1

Research Center for Chemistry, National Research and Innovation Agency Republic of Indonesia

Kawasan PUSPIPTEK Serpong, Kota Tangerang Selatan, Banten,

Indonesia

2

Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. DR. HAMKA

Jl. Limau II, Kebayoran Baru, Jakarta Selatan, Jakarta,

Indonesia

^a)Corresponding author: [email protected]; [email protected]

AIP Conf. Proc. 2493, 070025 (2022)

https://doi.org/10.1063/5.0110147

Artocarpus elasticus Reinw. ex Blume is a member of the Moraceae tribe, which contains prenylated phenolic compounds, especially flavonoids with different structural variations such as flavanones, flavones, xanthones, chalcone, and stilbene. This research aims to isolate, identify, and evaluate their antidiabetic activity from A. elasticus Reinw. ex Blume bark. The research method consisted of isolation by column chromatography based on bioassay-guided fractionation, characterization of isolate using UV-Vis, FTIR, LC-MS, and NMR spectroscopy and in vitro antidiabetic activity assay against a-glucosidase enzyme. This study obtained artoindonesianin C with the molecular formula of C₂₆H₂₂O_8. Antidiabetic activity against α-glucosidase inhibitor showed significant activity with IC₅₀ value of 31.88 µg/mL.

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