The aim of the research is to study the possibility of correcting hypothyroidism with a synthetic analogue of the opioid leu-enkephalin (dalargin). The research was carried out on 70 white outbred male rats. The animals were simulated experimental hypothyroidism by the introduction of a synthetic thyreostatic which is called mercazolil. The positive long-term corrective effect of dalargin on the production of thyroid hormones has been shown. Dalargin lowers corticosterone level and protects the body from the damaging effects of stress.
REFERENCES
1.
P. N.
Taylor
, D.
Albercht
, A.
Scholz
et al., Nature Reviews Endocrinology
14
(5
) 301
–306
(2018
). Doi: .2.
L. A.
Nikolaeva
, Materials of the All-Russian scientific-practical conference with international participation under.
ed. M.F.
Savchenkova
(Irkutsk). 2011
, 28
–35
.3.
4.
N. K.
Klichkhanov
, Zh. G.
Ismailova
, M. D.
Astaeva
, T. N.
Daudova
and L. T.
Tadjibova
, Bul. Of expert. biol. and medicine
4
443
–456
(2010
).5.
V. D.
Slepushkin
and A. A.
Nikolaev
, Palliative medicine and rehabilitation
1
5
–10
(2004
).6.
7.
A. V.
Nikolaev
, V. D.
Slepushkin
and I. P.
Vereshchagin
, Topical issues of intensive care
12
27
–29
(2003
).8.
F. Kh.
Kamilov
, T. I.
Ganeev
, V. N.
Kozlov
, E. V.
Kuznetsova
and R. R.
Maksyutov
, Biomedicine
1
59
–70
(2018
).9.
A. Kh.
Shantyz
, S. V.
Romashchenko
and I. A.
Yapparov
, Achievements of science and technology of the agro-industrial complex
7
72
–74
(2012
).10.
N. V.
Korobov
, The Bulletin of the Scientific Center for Expert Evaluation of Medical Products
4
93
–98
(2007
).11.
D. V.
Garmaeva
and L. S.
Vasilieva
, Fundamental science and technology - promising developments - North Charleston, SC USA
1
13
–15
(2014
).
This content is only available via PDF.
© 2022 Author(s).
2022
Author(s)
You do not currently have access to this content.