Study of the effect of intrauterine chlamydia infection on destruction of bovine offspring tissue

Significant economic damage to agricultural enterprises in Russia is caused by infectious diseases, in particular chlamydial infection of cattle, which is widespread in the population among productive animals. The agent of chlamydia is extremely virulent and pathogenic for intrauterine development of the fetus, as well as for adults in whom the disease has a latent or low-symptomatic course. The leading role of intrauterine infections, among the causes of adverse perinatal outcomes, determines the nature of a comprehensive study of this problem, in this regard, the study of tissues afterbirth (placenta, umbilical cord, fetal membranes) to find out the “break point” in the mother-placenta-fetus system, when the pathogen spreads freely to various organs and tissues of the fetus is most relevant. With chlamydial lesions of the placenta there developed pronounced pathological and compensatory reactions, circulatory disorders, dystrophic changes with disruption of the basic functions of the placental barrier. There were inflammatory reactions at the level of the vascular bed of the basal part of the villi, as well as endometrial stroma and villous stroma. The cellular composition of the inflammatory infiltrate indicated the chronic nature of inflammation on an immunopathological basis, while confirming the hematogenous route of the pathogen in fetal organs and tissues with imperfect immune response at the placental level and immature fetus with intracellular persistence of chlamydia. It was found that intrauterine chlamydia in cattle affected all parts of the system “mother-placenta-fetus”, resulting in stillbirth or birth of premature, sick, often non-viable offspring.