Vitamin D is a fat-soluble vitamin that aids in the assimilation of phosphorus and calcium in the body. It’s well-known for keeping calcium levels in check. Several studies have recently exposed that vitamin D plays a wide variety of roles in mineral equilibrium. Vitamin D synthesis pathways and receptors have been discovered in a number of tissues, where they play a crucial role in immune system regulation. In addition to osteomalacia and rickets, vitamin D deficiency is related to a number of bacterial and metabolic disorders. Vitamin D deficiency has been attributed to the spread of tuberculosis in latest studies. Vitamin D deficiency is typical in patients with pulmonary tuberculosis. As a outcome, sustaining vitamin D levels in pulmonary tuberculosis would be beneficial to tuberculosis treatment. Vitamin levels can be preserved at recommended levels by maintaining a balanced diet and taking multivitamin supplements. This analysis distinguishes the function of vitamin D in a variety of infectious diseases, including tuberculosis, as well as the impacts of supplement of vitamin D on TB care. Because of the clinical improvements seen in tuberculosis patients after vitamin D supplement, more research is needed.

1.
Jr.
Combs
,
F.
Gerald
, and
McClung
J. P.
 The vitamins: fundamental aspects in nutrition and health. (
Academic press
,
2016
).
2.
M.
Eggersdorfer
,
D.
Laudert
,
U.
Letinois
,
T.
McClymont
,
J.
Medlock
,
T.
Netscher
and
W.
Bonrath
.
One hundred years of vitamins—A success story of the natural sciences
.
AngewandteChemie International Edition.
21;
51[
52]
:
12960
90
(
2012
).
3.
K. Junaid andA.
Rehman
.
Impact of vitamin D on infectious disease-tuberculosis-a review
.
Clinical Nutrition Experimental.
1;
25
:
1
0
(
2019
).
4.
M. Wacker andMF.
Holick
. "
Vitamin D—effects on skeletal and extraskeletal health and the need for supplementation
."
Nutrients 5
, No.
1
:
111
148
(
2013
) .
5.
A.
Gil
,
J. Plaza-Diaz andMD.
Mesa
.
Vitamin D: classic and novel actions
.
Annals of Nutrition and Metabolism.
72[
2]
:
87
95
(
2018
).
6.
C.
Dini
and
A.
Bianchi
.
The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases
.
Annalidell’Istitutosuperiore di sanita.
48
:
319
27
(
2012
).
7.
A. Giustina andJP.
Bilezikian
.
Vitamin D in Clinical Medicine
.
Karger Medical and Scientific Publishers
. Mar 29 (
2018
).
8.
AC.
Ross
,
JE.
Manson
,
SA.
Abrams
,
JF.
Aloia
,
PM.
Brannon
,
SK.
Clinton
,
RA.
Durazo-Arvizu
,
JC.
Gallagher
,
RL.
Gallo
,
G. Jones andCS.
Kovacs
.
The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know
.
The Journal of Clinical Endocrinology & Metabolism.
Jan 1;
96
[
1
]:
53
8
(
2011
).
9.
D.D.
Bikle
.
Vitamin D metabolism, mechanism of action, and clinical applications
.
Chemistry & biology
. Mar 20;
21
[
3
]:
319
29
(
2014
).
10.
G.
Jacquillet
,
R.J.
Unwin
.
Physiological regulation of phosphate by vitamin D, parathyroid hormone [PTH] and phosphate [Pi]
.
PflügersArchiv-European Journal of Physiology. Jan 31
;
471[
1]
:
83
98
(
2019
).
11.
M.F.
Holick
,
T.C.
Chen
.
Vitamin D deficiency: a worldwide problem with health consequences
.
The American journal of clinical nutrition. Apr 1
;
87[
4]
:
1080S
6S
(
2008
).
12.
O.
Tsuprykov
,
X.
Chen
,
CF.
Hocher
,
R.
Skoblo
,
L. Yin andB.
Hocher
.
Why should we measure free 25 [OH] vitamin D?
.
The Journal of steroid biochemistry and molecular biology. Jun 1
;
180
:
87
104
(
2018
).
13.
M.F.
Holick
,
N.C.
Binkley
,
H.A.
Bischoff-Ferrari
,
C.M.
Gordon
,
D.A.
Hanley
,
R.P.
Heaney
,
M.H.
Murad
and
C.M.
Weaver
.
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline
.
The Journal of Clinical Endocrinology & Metabolism
. Jul 1;
96
[
7]
:
1911
30
(
2011
).
14.
V.R.
Viraraghavan
,
A.
Seth
,
S.
Aneja
,
R.
Singh
and
D.
Dhanwal
.
Effect of high dose vitamin d supplementation on vitamin d nutrition status of pre-pubertal children on anti-epileptic drugs e A randomized controlled trial
.
The Journal of Clinical Nutrition ESPEN.
;
29
:
36
40
(
2019
).
15.
D.
Bikle
.
Vitamin D: production, metabolism, and mechanisms of action
.
Book from MDText.com, Inc., South Dartmouth [MA]
, (24 Apr
2015
)
16.
H.G.
Mikail
.
From Nutrition to Health: The Role of Natural Products–A Review
.
Phytochemicals: Bioactivities and Impact on Health. Dec 22
:
201
(
2011
).
17.
M.F.
Holick
.
The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action
.
Molecular aspects of medicine. Dec 1
;
29[
6]
:
361
8
(
2008
).
18.
World Health Organization
. Global tuberculosis control 2009: epidemiology, strategy, financing: WHO report 2009.
Geneva
:
World Health Organization
; p.
303
(
2009
).
19.
www.emro.who.int/irq/programmes/tuberculosis.html#:∼:text=TB is a
public health,are more than 4000 annually. WHO EMRO | Tuberculosis | Programmes | Iraq
(
2021
) .
20.
K.K.
Lee
,
H.J.
Milburn
.
Environmental Factors Contributing to Susceptibility to Tuberculosis
.
Current Respiratory Medicine Reviews. Jun 1
;
9[
3]
:
163
71
(
2013
).
21.
A.R.
Martineau
.
Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis
.
Proceedings of the Nutrition Society.
71[
1]
:
84
9
(
2012
).
22.
M.
Martini
,
V.
Gazzaniga
,
M.
Behzadifar
,
N.L.
Bragazzi
and
I.
Barberis
.
The history of tuberculosis: the social role of sanatoria for the treatment of tuberculosis in Italy between the end of the 19th century and the middle of the 20th
.
Journal of preventive medicine and hygiene. Dec
;
59[
4]
:
E323
(
2018
).
23.
A.J.
Battersby
,
B.
Kampmann
and
S.
Burl
.
Vitamin D in early childhood and the effect on immunity to Mycobacterium tuberculosis
.
Clinical and Developmental Immunology
. Jan 1;2012 (
2012
).
24.
G.A.
Rook
,
J.
Steele
,
L.
Fraher
,
S.
Barker
,
R.
Karmali
,
J.
O’riordan
and
J.
Stanford
.
Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes
.
Immunology.
57[
1]
:
159
(
1986
).
25.
P.T.
Liu
,
S.
Stenger
,
H.
Li
,
L.
Wenzel
,
B.H.
Tan
,
S.R.
Krutzik
,
M.T.
Ochoa
,
J.
Schauber
,
K.
Wu
,
C.
Meinken
and
D.L.
Kamen
.
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
.
Science.
Mar 24;
311[
5768]
:
1770
3
(
2006
).
26.
R.F.
Chun
,
J.S.
Adams
and
M.
Hewison
.
Immunomodulation by vitamin D: implications for TB
.
Expert review of clinical pharmacology
.
1
;4[
5
]:
583
91
(
2011
).
27.
V.
Tangpricha
,
S.E.
Judd
,
T.R.
Ziegler
,
L.
Hao
,
J.A.
Alvarez
,
A.M.
Fitzpatrick
,
G.A.
McComsey
and
A.R.
Eckard
.
LL-37 concentrations and the relationship to vitamin D, immune status, and inflammation in HIV-infected children and young adults
.
AIDS research and human retroviruses.
Jul 1;
30[
7]
:
670
6
(
2014
).
28.
A.
Sonawane
,
J.C.
Santos
,
B.B.
Mishra
,
P.
Jena
,
C.
Progida
,
O.E.
Sorensen
,
R.
Gallo
,
R.
Appelberg
and
G.
Griffiths
.
Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages
.
Cellular microbiology. Oct;13[
10]
:
1601
17
(
2011
).
29.
K.
Park
,
P.M.
Elias
,
Y.
Oda
,
D.
Mackenzie
,
T.
Mauro
,
W.M.
Holleran
and
Y.
Uchida
.
Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum [ER] stress signaling, vitamin D receptor-independent pathway
.
Journal of Biological Chemistry
. Sep 30;
286
[
39
]:
34121
30
(
2011
).
30.
P.T.
Liu
,
M.
Schenk
,
V.P.
Walker
,
P.W.
Dempsey
,
M.
Kanchanapoomi
,
M.
Wheelwright
,
A.
Vazirnia
,
X.
Zhang
,
A.
Steinmeyer
,
U.
Zügel
and
B.W.
Hollis
.
Convergence of IL-1β and VDR activation pathways in human TLR2/1-induced antimicrobial responses
.
PloS one. Jun 5
;
4[
6]
:
e5810
(
2009
).
31.
T.T.
Wang
,
B.
Dabbas
,
D.
Laperriere
,
A.J.
Bitton
,
H.
Soualhine
,
L.E.
Tavera-Mendoza
,
S.
Dionne
,
M.J.
Servant
,
A.
Bitton
,
E.G.
Seidman
and
S.
Mader
.
Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin β2 innate immune pathway defective in Crohn disease
.
Journal of Biological Chemistry
. Jan 22;
285
[
4
]:
2227
31
(
2010
).
32.
C.
Ogawa
,
Y.J.
Liu
,
K. S.
Kobayashi
.
Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy
.
Current bioactive compounds
. Sep 1;
7
[
3
]:
180
97
(
2011
).
33.
C.S.
Yang
,
D.M.
Shin
,
K.H.
Kim
,
Z.W.
Lee
,
C.H.
Lee
,
S.G.
Park
,
Y.S.
Bae
and
E.K.
Jo
.
NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression
.
The Journal of Immunology.
Mar 15;
182
[
6
]:
3696
705
(
2009
).
34.
S.
Nicholson
,
M.D.
Bonecini-Almeida
,
J.R. Lapa e
Silva
,
C.
Nathan
,
Q.W.
Xie
,
R.
Mumford
,
J.R.
Weidner
,
J.
Calaycay
,
J.
Geng
,
N.
Boechat
and
C.
Linhares
.
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis
.
The Journal of experimental medicine. May 1
;
183[
5]
:
2293
302
(
1996
).
35.
N.
Sutaria
,
C.T. Liu andT.C.
Chen
.
Vitamin D status, receptor gene polymorphisms, and supplementation on tuberculosis: a systematic review of case-control studies and randomized controlled trials
.
Journal of clinical & translational endocrinology. Dec 1
;
1[
4]
:
151
60
(
2014
).
36.
K.E.
Nnoaham
and
A.
Clarke
.
Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis
.
International journal of epidemiology. Feb 1
;
37[
1]
:
113
9
(
2008
).
37.
D.
Khandelwal
,
N.
Gupta
,
A.
Mukherjee
,
R.
Lodha
,
V.
Singh
,
H.M.
Grewal
,
S.
Bhatnagar
,
S.
Singh
and
S.K.
Kabra
,
Delhi Pediatric TB Study Group. Vitamin D levels in Indian children with intrathoracic tuberculosis
.
The Indian journal of medical research. Oct
;
140[
4]
:
531
(
2014
).
38.
N.
Talat
,
S.
Perry
,
J.
Parsonnet
,
G.
Dawood
and
R.
Hussain
.
Vitamin D deficiency and tuberculosis progression
.
Emerging infectious diseases
. May;16[
5
]:
853
(
2010
).
39.
S.K.
Jabal
,
L.Y.
Mohammed
and
A.A.
Mankh
.
Association of Vitamin D level with Tuberculosis in Iraqi patients
.
Al-Nisour Journal for Medical Sciences.
;
2[
1]
(
2020
).
40.
A.R.
Martineau
,
A.C.
Leandro
,
S.T.
Anderson
,
S.M.
Newton
,
K.A.
Wilkinson
,
M.P.
Nicol
,
S.M.
Pienaar
,
K.H.
Skolimowska
,
M.A.
Rocha
,
V.C.
Rolla
and
M.
Levin
.
Association between Gc genotype and susceptibility to TB is dependent on vitamin D status
.
European Respiratory Journal
. May 1;
35
[
5
]:
1106
12
(
2010
).
41.
A.
Afzal
,
R.
Rathore
,
N.F.
Butt
and
F.A.
Randhawa
.
Efficacy of vitamin D supplementation in achieving an early sputum conversion in smear positive pulmonary tuberculosis
.
Pakistan journal of medical sciences
. Jul;
34
[
4
]:
849
(
2018
).
42.
J.
Zhang
,
C.
Chen
and
J.
Yang
.
Effectiveness of vitamin D supplementation on the outcome of pulmonary tuberculosis treatment in adults: a meta-analysis of randomized controlled trials
.
Chinese medical journal. Dec
20;
132
[
24
] (
2019
).
43.
W.A.
Ji
,
F.E.
Malong
,
Y.I.
Shidong
,
Z.H.
Jianfang
,
L.I.
Xiaoqing
.
Efficacy and safety of vitamin D supplementation for pulmonary tuberculosis: a systematic review and meta-analysis
.
Iranian journal of public health. Apr
;
47[
4]:466
(
2018
).
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