The present study was conducted to diagnose the ability of growth hormone releasing peptide (GHRP-6) or growth hormone secreting factors (GHS) secretagogues to treat gonadal dysfunction caused mainly by low testosterone levels induced by the anabolic steroid drug oxymetholone and then evaluation growth hormone(GH), testosterone levels, in addition to evaluate its effect to hormone levels of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin Hormone (PRL) and Estradiol (E2) and all of which were estimated in the sera of white rabbits. The study design were divided into 4 groups (3 treatment groups each containing 11 rabbits+a control group (as a control sample). Then the blood was taken and the sera separated after the end of the prescribed dose and injection period for each group, The results of the analysis are as follows: There were no significant differences in the levels of growth hormone (GH) for the G1 group, while showed a significant increase in the groups of G2,G3, and this increase was higher for a group of G2 than for G3. The results showed a significant decrease in the testosterone levels of the G1 group, and a significant increase in its levels for the G2 group, while no significant differences were observed for the G3 group, and the results also showed a significant decrease in the levels of the luteinizing hormone (LH) of the G1 group and a significant increase in its levels for the G2 group while no significant differences were observed for the G3 group, as well as the results showed no significant difference in the follicle stimulating hormone (FSH) levels of the G1 and G2 groups, and it showed a significant increase in its levels in the G3 group, with respect to prolactin (PRL) The results showed a significant increase in the G1 group, and the G2, G3 groups did not show any significant differences, estradiol(E2) showed a significant increase in its levels in the G1 ,G2 groups, and no significant differences in its levels in the G3 group, noting that all the results mentioned above were compared with the control group C.
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