In a case-control study, fifty two subjects with COVID-19 were included in the study and 30 gender and age matched apparently healthy individuals were included as control. Vitamin D serum level determined by Mini Vidus, WBC, Lymphocytes and PCV by Swelab. CRP determined manually. SPSS package used for statistical analysis. Vitamin D mean serum level in COVID-19 subjects was significantly lower [P=0.007] than that in control group. Vitamin D mean serum value was lower than normal recommended value in patients with COVID-19. Additionally, the frequency of < 10 ng/ml was 30% in controls, while it was 42% in patients group. When the results stratified on < 20 ng/ml strata, controls show 70%, while patients corresponding value was 81%. The mean serum levels of vitamin D were higher in male compared to female, in smoker as compared to non-smoker and in patients with age of ≥ 50 years. However, the differences not reach significant values. There was inverse correlation between Vitamin D low serum levels and CRP levels indicating a significant association between disease severity and vitamin D serum levels. Serum vitamin D was higher in patients with chronic diseases than that in patients without chronic diseases history, however, the difference not reach significant level.

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