Association between calcium-sensing receptor gene polymorphism A986S and some calcium-related parameters in pregnant women Available to Purchase

There are a few studies about the relationship between genetic polymorphism with metabolic and hormonal changes that occur during pregnancy. Therefore, the study aimed to assess the calcium-sensing receptor (CaSR) gene polymorphism A986S and its association with calcium-related parameters through three trimesters in Iraqi pregnant women. Blood samples were collected from (66) pregnant women and (24) women as a control from the private clinics. Calcium, albumin, phosphorus, alkaline phosphatase, vitamin D and parathyroid hormone were measured by spectrophotometer and ELISA assay. Genomic DNA extracted from the whole blood then used in polymerase chain reaction fragment length polymorphism method to detect CaSR polymorphism A986S. Calcium and vitamin D levels were low while parathyroid hormone, phosphorus, albumin and alkaline phosphatase levels were significantly higher (p value < 0.01) in pregnant women compared to control. There is a significant decrease in calcium and vitamin D levels reverse parathyroid hormone and phosphorus in 3^rd compared to the 1^st and 2^nd trimester in pregnant women. A negative and positive correlation was found between calcium and other parameters. The frequency of genotypes and alleles were non-significant. The pregnant women carrying S allele had high parathyroid hormone and alkaline phosphate levels, while, carrying A allele had decreased levels of calcium, vitamin D, albumin and phosphorus. In conclusion, calcium and vitamin D deficiency was common during pregnancy, especially in 3^rd trimester and there is a correlation between calcium with vitamin D and parathyroid hormone levels. The CaSR polymorphism A986S is one of the genetic factors that have effects on the calcium-related parameters.