Synthesis of methyl 7-formylabieta-7,13-dien-18-oate was achieved by formylation of the abietic acid methyl ester under Vilsmeier-Haack conditions. The in vitro cytotoxicity of the abietic and dehydroabietic acid derivatives against the NCI-60 cancer cell line panel was also studied. The dehydroabietic acid aminopropargyles showed promising antitumor activity against leukemia CCRF-CEM and RPMI-8226 cancer cell lines.
Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives
E. V. Tretyakova, E. V. Salimova, L. V. Parfenova; Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives. AIP Conf. Proc. 4 February 2022; 2390 (1): 020080. https://doi.org/10.1063/5.0069202
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