Bacterial profile in skin ulcer infection with special resistance to antibiotics in AL-Sader hospital in Al-Najaf city

Skin ulcer infections and Diabetic foot ulcer (DFU) are wide clinical spectrum common causes of hospitalization and require acute antibiotic treatment that associated with wide range of pathogens which characterized with resistance against wide range of antibiotics that lead to failure therapy. The aim of the study was investigation bacterial profile, antibiotic resistance of isolated bacteria in skin and Diabetic foot ulcer patient and the effect of degree the ulcer patients. This study included 90 pus samples were collected from patients having skin ulcer and diabetic foot ulcer attended to AL-sader hospital during period 1-9 /2019. This study has shown that higher frequency of DFU and skin ulcer patients was male and the median of age in the patients were older than 40 years. Culture investigation shows that 82 specimens give positive growth of bacteria with total bacterial growth 94 isolates, 70 (74.5%) of cases had mono-microbial infection whereas 24 (25.5%) of cases give poly-microbial infection. Out of 94 bacterial isolates, 53 (56.4 %) isolates were gram negative bacteria (G-ve), which includes P.aerogenosa was 18 (33.96%) isolates, followed by K.pneumonia 11 (20.75%) isolates, Proteus spp 9 (16.98%) isolates, then E.coli 8 (15%) isolates, Citrobacter freundii 3 (7.5%) isolates and Acinetobacter baumanni 4 (5.6%) isolates, whereas G^+ve bacteria recorded 41 (43.6%), which include S. aureus as predominant isolated bacteria in this study that record 14 (34.14 %) isolates followed by S. pyogenes was 9 (21.95%) isolates, then S. epidermedes, S. haemolyticus and E. fecalis 8 (19.51%), 6 (14.63%) and 4 (9.75%) isolates respectively. In this study the predominance bacteria isolated of superficial in Diabetic foot and skin ulcer were S. aureus while most bacteria presented of Deep ulcer in both ulcers were P. aerogenosa. The results of antibiotic resistance show most isolates in G^+ve were sensitive to Vancomycin and high resistance to Gentamycin, Penicillin and Erythromycin whereas most G^−ve isolates were resistant to Ampicilline, gentamicin, Pipercillin/tazobactam and sensitive to imipenem.