Newcastle disease virus (NDV) is promising antitumor agent that triggers immediate cytolysis of the tumor, apoptosis and activation of the immune system. This study was aimed at testing the antiangiogenic NDV Performance on a model of breast cancer. NDV has been studied against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine the antitumor activity of NDV in vivo. Histopathological sections for the treated tumor mass demonstrated proliferation of granulation tissue with substantial necrosis region. This study indicated the role of Iraqi strain NDV in reducing the volume of solid tumor when compared with untreated group which is confirmed feature that make NDV Iraqi strain as anti-tumor agents.
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11 November 2021
2nd International Conference in Physical Science & Advanced Materials: PAM2020
24–27 October 2020
Dubai, United Arab Emirates
Research Article|
November 11 2021
In vivo oncolytic activity of non-virulent newcastle disease virus Iraqi strain against mouse mammary adenocarcinoma
Shatha M. Ali;
Shatha M. Ali
a)
1
Uruk University
, Baghdad, Iraq
a)Corresponding author: [email protected]
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Bahaa A. Lafta;
Bahaa A. Lafta
2
Biology Department, college of Science, University of Baghdad
, Baghdad, Iraq
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Ahmed Majeed Al-Shammary;
Ahmed Majeed Al-Shammary
3
Experimental Therapy Department, Iraqi Center for Cancer and Medical Genetics Research, AL-Mustansiriyah University
, Baghdad, Iraq
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Hasnain S. Salih
Hasnain S. Salih
4
Al-Bayan University
, Baghdad, Iraq
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a)Corresponding author: [email protected]
AIP Conf. Proc. 2372, 030010 (2021)
Citation
Shatha M. Ali, Bahaa A. Lafta, Ahmed Majeed Al-Shammary, Hasnain S. Salih; In vivo oncolytic activity of non-virulent newcastle disease virus Iraqi strain against mouse mammary adenocarcinoma. AIP Conf. Proc. 11 November 2021; 2372 (1): 030010. https://doi.org/10.1063/5.0067194
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