Newcastle disease virus (NDV) is promising antitumor agent that triggers immediate cytolysis of the tumor, apoptosis and activation of the immune system. This study was aimed at testing the antiangiogenic NDV Performance on a model of breast cancer. NDV has been studied against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine the antitumor activity of NDV in vivo. Histopathological sections for the treated tumor mass demonstrated proliferation of granulation tissue with substantial necrosis region. This study indicated the role of Iraqi strain NDV in reducing the volume of solid tumor when compared with untreated group which is confirmed feature that make NDV Iraqi strain as anti-tumor agents.

1.
N. K.
Phan
,
Biological therapy: a new age of cancer treatment
.
Biomedical Research and Therapy
,
2
(
1
),
1
3
. (
2014
)
2.
J. R.
Tysome
,
N. R.
Lemoine
, and
Y.
Wang
,
Update on oncolytic viral therapy–targeting angiogenesis
.
On coTargets and therapy
,
6
,
1031
(
2013
).
3.
A. M.
Al-Shammari
,
F. E.
Ismaeel
,
S.M.
Salih
, and
N. Y.
Yaseen
,
Live attenuated measles virus vaccine therapy for locally established malignantglioblastoma tumor cells
.
Oncolytic Virother.
3
,
57
68
(
2014
).
4.
A. M.
Al-Shammari
,
N.
Yaseen
,
M.
Alwan
Eur J Cancer Suppl
8
:
171
(
2010
).
5.
A.M.
Al-Shammary
,
H.H.
Hassani
, and
U.A.
Ibrahim
.
Journal of Biology and Life Sciences.
5
:
1
(
2014
).
6.
Salih
,
R.H.
Adv. Anim. Vet. Sci.
5
(
11
):
436
445
(
2017
).
7.
A. M.
Al-Shammari
,
N.
Yaseen
, M.
J. Alwan Iraqi Journal of Cancer.
1,
1
(
2008
).
8.
A. M.
Hamza
,
Newcastle disease Virus therapy for transplanted tumors in combination with chemotherapy
, Ph.D. Thesis,
Collage of Veterinary Medicine, University of Baghdad
2009
.
9.
A.
Al-Shamery
,
The study of newcastle disease virus effect in the treatment of transplanted tumors in mice.
MVM Thesis,
College of Veterinary Medicine, University of Baghdad
,
Baghdad, Iraq
,
2003
.
10.
S.
Guedan
,
J. J.
Rojas
,
A.
Gros
,
E.
Mercade
,
M.
Cascallo
, and
R.
Alemany
,
Molecular Therapy
,
18
,
1275
1283
(
2010
).
11.
V.
Schirrmacher
,
A.
Griesbach
,
T.
Ahlert
,
Int. J. Oncol
,
18
,
945
952
(
2001
).
12.
T.
Shay
Z-R.
Zichria
,
P.
Amos
.
Therapeutic potential of oncolytic Newcastle disease virus: a critical review
,
Oncolytic Virother.
2015
;
4
:
49
62
.
13.
M.
Mayo
,
A summary of taxonomic changes recently approved by ICTV
.
Archives of virology.
147
,
1655
1656
(
2002
).
This content is only available via PDF.
You do not currently have access to this content.