Biological therapy is opening up a new age for the treatment of cancer. The bacteria -cancer interaction was firstly observed by Busch and Fehleisen (1). To reducing the potential of pathogenicity of using active bacterial, using bacterial products like proteins, enzymes, immune-toxins, that straightaway target malignancy cells and regress the volume of the tumor through expansion inhibition, induction of apoptosis (2). This study was aimed at testing the antiangiogenic bacterial neuraminidase against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice through intratumoral injection to determine the antitumor activity in vivo. Histopathological sections for the treated tumor mass demonstrated proliferation of granulation tissue with substantial necrosis region. This study indicated the role of bacterial neuraminidase in reducing the volume of the solid tumor when compared with an untreated group which is a confirmed feature that makes it as anti-tumor agent.

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