Cytotoxicity, antioxidant activity, and a total bioactive assay of the ethanolic extract of Annona muricata leave partitioned into water, n-hexane, and methanol fractions were investigated. The brine shrimp lethality test used for the cytotoxicity assay gave the LC50 values of 84 and 1 ppm for the n-hexane and methanol fractions, respectively. The antioxidant activity determined using DPPH reagent gave IC50 values of 40, 15, and 8 ppm for the n-hexane, water, and methanol fractions, respectively. In addition, the total polyphenol and the total acetogenin content of the methanol fraction were also the highest among the three fractions. These results indicate that the methanol fraction of the Annona muricata has the highest potential as a source for naturally occurring antitumor and antioxidant compounds.
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23 March 2021
THE 5TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 5th International Symposium of Biomedical Engineering (ISBE) 2020
28–29 July 2020
Depok, Indonesia
Citation
Elsa Anisa KrisantiAfidya Indina HarumantiKamarza Mulia; Annona muricata leaves ethanolic extract in water, n-hexane, and methanol fractions: Cytotoxicity assay, antioxidant activity, flavonoid content, polyphenol content, and acetogenin content. AIP Conf. Proc. 23 March 2021; 2344 (1): 040004. https://doi.org/10.1063/5.0047484
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