Masseter muscle is one of the masticatory muscles functioning in mandibular elevation. Its anatomical structure is closely related to the underlying skeletal structure. Thus, changes happened in the muscle structure will affect the growth of the jawbones. Numerical studies have been conducted to demonstrate and correlate the changes in masseter muscle to the skeletal malocclusion. Changes in fiber type properties, genetic, and epigenetic expression of masseter muscle resulting in a significant correlation to specific malocclusion. Single nucleotide polymorphisms (SNPs) is a common type of genetic variation that induced changes in genetic expression of masseter muscle. Nonsense mutation of R577X in ACTN3 gene is one evidence of genetic expression influence on developing skeletal deep-bite malocclusion. While epigenetic mechanism of acetylation and deacetylation promote by acetyltransferase (KAT) and deacetylase (HDAC) will give influence on the transcription of MHC gene.

1.
Drake
FL
.
Vogl
AW
.
Mitchell
AWM
.
Head
and
Neck
. In:
Gray’s Atlas of Anatomy
.
Second Edi. Churcill Livingston: Elsevier
;
2015
:
475
608
.
2.
Azaroual
MF
,
Fikri
M
,
Abouqal
R
,
Benyahya
H
,
Zaoui
F.
Relationship between dimensions of muscles of mastication (masseter and lateral pterygoid) and skeletal dimensions: Study of 40 cases
.
International Orthodontics.
2013
.
3.
Cakan
DG
,
Ulkur
F
,
Taner
TU
.
The genetic basis of facial skeletal characteristics and its relation with orthodontics
.
Eur J Dent.
2012
;
6
(
3
):
340
345
. doi:
4.
Rowlerson
A
,
Raoul
G
,
Daniel
Y
, et al.
Fiber-type differences in masseter muscle associated with different facial morphologies
.
Am J Orthod Dentofac Orthop.
2005
;
127
(
1):37
46
. doi:
5.
Zebrick
B
,
Teeramongkolgul
T
,
Nicot
R
, et al.
ACTN3 R577X genotypes associate with Class II and deep-bite malocclusions
.
Am J Orthod Dentofac Orthop.
2014
;
146
(
5
):
603
611
. doi:
6.
Huh
A
,
Horton
MJ
,
Cuenco
KT
, et al.
Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion
.
Am J Orthod Dentofac Orthop.
144
(
4
):
568
576
. doi:
7.
Joshi
N
,
Hamdan
AM
,
Fakhouri
WD
.
Skeletal Malocclusion: A Developmental Disorder With a Life-Long Morbidity
.
J Clin Med Res.
2014
;
6
(
6
):
399
408
. doi:
8.
da Fontoura
CSG
,
Miller
SF
,
Wehby
GL
, et al.
Candidate Gene Analyses of Skeletal Variation in Malocclusion
.
J Dent Res.
2015
;
94
(
7
):
913
920
. doi:
9.
Lopatiene
K
,
Sidlauskas
A
,
Vasiliauskas
A
,
Cecyete
L
,
Svalkauskiene
V
,
Sidlauskas
M.
Relationship between malocclusion, soft tissue profile, and pharyngeal airways: A cephalometric study
.
Med.
2016
;
52
(
5
):
307
314
. doi:
10.
Uribe
LMM
,
Vela
KC
,
Kummet
C
,
Dawson
D V.
,
Southard
TE
.
Phenotypic diversity in white adults with moderate to severe Class III malocclusion
.
Am J Orthod Dentofac Orthop.
2013
;
144
(
1
):
32
42
. doi:
11.
Lin
L-H
,
Huang
G-W
,
Chen
C-S.
Etiology and Treatment Modalities of Anterior Open-bite Malocclusion
.
J Exp Clin Med.
2013
;
5
(
1
):
1
4
. doi:
12.
El-dawlatly
MM
,
Fayed
MMS
,
Mostafa
YA
.
Deep overbite malocclusion : Analysis
.
AJO-DO.
2017
;
142
(
4
):
473
480
. doi:
13.
Pepicelli
A
,
Woods
M
,
Briggs
C.
The mandibular muscle and their importance in orthodontics : A contemporary review
.
AJO.
2005
;
128
(
6
):
774
780
. doi:
14.
Kiliaridis
S.
The Importance of Masticatory Muscle Function in Dentofacial Growth
.
Semin Orthod.
2006
;
12
(
2
):
110
119
. doi:
15.
Tsai
CY
,
Lin
YC
,
Su
B
,
Yang
LY
,
Masseter
WCC
.
Masseter muscle fibre changes following reduction of masticatory function
.
Int J Oral Maxillofac Surg.
2012
;
41
:
394
399
. doi:
16.
Rani
S
,
Ravi
MS
.
Masseter muscle thickness in different skeletal morphology : An ultrasonographic study
.
Indian J Dent Res.
2010
;
21
(
3
):
402
407
. doi:
17.
Anastasi
GP
,
Rc
GM
,
Cutroneo
WG
,
Piancino
PBMG
.
Functional and molecular outcomes of the human masticatory muscles
.
2018
;(September 2017):
1428
1441
. doi:
18.
Sciote
JJ
,
Horton
MJ
,
Rowlerson
AM
,
Ferri
J
,
Close
JM
,
Raoul
G.
Human masseter muscle fiber type properties, skeletal malocclusions, and muscle growth factor expression
.
J Oral Maxillofac Surg.
2012
;
70
(
2
):
440
448
. doi:
19.
Sciote
JJ
,
Raoul
G
,
Ferri
J
,
Close
J
,
Horton
MJ
,
Rowlerson
A.
NIH Public Access
.
Masseter Funct Skelet malocclusion.
2013
;
114
(
2
):
1
14
. doi:
20.
Seiryu
M
,
Daimaruya
T
,
Iikubo
M
,
Watanabe
K.
Decreases of occlusal vertical dimension induce changes in masticatory muscle fiber composition
.
Orthod Waves.
2012
;
71
:
123
128
.
21.
Cunha
A
,
Nelson-filho
P
,
Marañón-vásquez
GA
, et al.
Archives of Oral Biology Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns
.
Arch Oral Biol.
2019
;
97
(July 2018):
85
90
. doi:
22.
Hartsfield
JK
 Jr.
Morford
LA
. Genetics in Orthodontics. In:
Orthodontics Current Principle and Techniques
. Sixth Edit.
St Louis: Elsevier
;
2017
:
31
45
.
23.
Desh
H
,
Gray
SL
,
Horton
MJ
,
Raoul
G
,
Rowlerson
AM
,
Ferri
J
, et al.
ScienceDirect Molecular motor MYO1C, acetyltransferase KAT6B and osteogenetic transcription factor RUNX2 expression in human masseter muscle contributes to development of malocclusion
.
Arch Oral Biol [Internet].
2014
;
59
(
6
):
601
7
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