Ruta angustifolia is a medicinal plant often used in treating various diseases. Several studies have been carried out to reveal the chemical compounds in this plant, and some are effectively used as antimicrobials. Candida albicans is the most common pathogenic fungus in humans and causes many cases of infection. C. albicans can form biofilms on biotic and abiotic surfaces, either as mono or multispecies, that may increase its pathogenicity. In a state of forming biofilms, microbes are surrounded by an extracellular matrix that protects the microbial community from antimicrobial agents. In this study, we examined the effect of R. angustifolia extract on C. albicans biofilm formation. C. albicans preformed biofilms (24 h) were treated with various concentrations of R. angustifolia extract (100%, 50%, 20%) and incubated at 37°C for 24 h. The characteristics of biofilm formation were assessed with microscopic methods using a light microscope. The results indicated that the effect of R. angustifolia extract could inhibit the C. albicans hypha formation at all concentrations treated.
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2 April 2021
THE 2ND SCIENCE AND MATHEMATICS INTERNATIONAL CONFERENCE (SMIC 2020): Transforming Research and Education of Science and Mathematics in the Digital Age
8–9 August 2020
Jakarta, Indonesia
Research Article|
April 02 2021
Inhibition of Candida albicans hypha formation in biofilm formation by Ruta angustifolia extract
Shafa Noer;
Shafa Noer
a)
1
Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia
, Depok 16424, Indonesia
3
Department of Biological Education, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indraprasta PGRI
, Jakarta 13760, Indonesia
a)Corresponding author: shafa_noer@yahoo.co.id
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Abinawanto;
Abinawanto
b)
1
Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia
, Depok 16424, Indonesia
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Boy M. Bachtiar;
Boy M. Bachtiar
2
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia
, Jakarta 10430, Indonesia
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Anom Bowolaksono
Anom Bowolaksono
1
Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia
, Depok 16424, Indonesia
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a)Corresponding author: shafa_noer@yahoo.co.id
AIP Conference Proceedings 2331, 050003 (2021)
Citation
Shafa Noer, Abinawanto, Boy M. Bachtiar, Anom Bowolaksono; Inhibition of Candida albicans hypha formation in biofilm formation by Ruta angustifolia extract. AIP Conference Proceedings 2 April 2021; 2331 (1): 050003. https://doi.org/10.1063/5.0041682
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