This research is about the implementation of e-module based on Problem Based Learning (PBL) to knows the creative thinking skills and cognitive learning outcomes. Creative thinking skills are skills in 21st century learning to measure students’ learning problem-solving abilities. The research method used was a pre-experimental one-group pretest- posttest design in the Endocrinology class, biology study program, State University of Malang. The results of the study were seen from the acquisition of pretest and posttest scores for the experimental class. The average pretest score for creative thinking skills was 51.7 and the posttest average score was 72.1 with a gain score of 0.39. The mean value of the pretest cognitive learning outcomes 34.4 and the average posttest 63.3 with gain value of 0.4. The results showed that the implementation of PBL-based e-module could improve students’ creative thinking skills and cognitive learning outcomes in biology students’ endocrinology material.

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