Infection is the entry of bacteria or pathogenic microorganisms into the body that can cause pain. For example, Staphylococcus aureus infection is caused by direct contamination of wounds, either post-surgical or infection after trauma. This study aims to determine the effectiveness of nano doxycycline as an exogenous photosensitizer agent in antimicrobial photodynamic inactivation (PDI) by using laser diode activator (403±0.02) nm against Staphylococcus aureus bacteria. The study was divided into three groups which were T0 as the untreated control group, T1 as treatment group with nano doxycyclin but without laser exposure, T2 as Treatment group with nano doxycyclin and laser treatments at various exposure times (30, 60, 90, 120, 150) seconds. This study used the Total Plate Count (TPC) method to find out the percentage decrease in the number of colonies. The results of statistical analysis showed that there were significant differences in the number of bacterial colonies due to the addition of nano doxycycline 0.1% and laser diode exposure (403.00±0.02) nm at (150.00±0.01) second with a energy density of (21.83±0.02) J/cm2. The results showed the addition of nano doxycycline was effective to reduce the number of bacterial colonies with a percentage of deaths of (85.34±1.20)%. So, antimicrobial photodynamic inactivation using laser diode with nano doxycyclin is effective to reduce the number of S. aureus bacteria.
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9 December 2020
THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019
22 October 2019
Surabaya, Indonesia
Research Article|
December 09 2020
Photodynamic inactivation effect of laser diode on Staphylococcus aureus bacteria with exogenous photosensitizer nano doxycycline 0.1%
Suryani Dyah Astuti;
Suryani Dyah Astuti
a)
1
Department of Physics Faculty of Science and Technology, Airlangga University
, Surabaya 60115, Indonesia
2
Biomedical Engineering Master Degree, Department of Physics, Faculty of Science and Technology, Universitas Airlangga
, Surabaya 60115, Indonesia
a)Corresponding author: [email protected]
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Dian Ayu Risma;
Dian Ayu Risma
b)
1
Department of Physics Faculty of Science and Technology, Airlangga University
, Surabaya 60115, Indonesia
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Andi Hamim Zaidan;
Andi Hamim Zaidan
c)
1
Department of Physics Faculty of Science and Technology, Airlangga University
, Surabaya 60115, Indonesia
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Putri Suryaning Puspita
Putri Suryaning Puspita
d)
3
Magister of Physics Engineering, Institute of Technology Sepuluh Nopember
, Surabaya 60111, Indonesia
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Suryani Dyah Astuti
1,2,a)
Dian Ayu Risma
1,b)
Andi Hamim Zaidan
1,c)
Putri Suryaning Puspita
3,d)
1
Department of Physics Faculty of Science and Technology, Airlangga University
, Surabaya 60115, Indonesia
2
Biomedical Engineering Master Degree, Department of Physics, Faculty of Science and Technology, Universitas Airlangga
, Surabaya 60115, Indonesia
3
Magister of Physics Engineering, Institute of Technology Sepuluh Nopember
, Surabaya 60111, Indonesia
a)Corresponding author: [email protected]
AIP Conf. Proc. 2314, 060004 (2020)
Citation
Suryani Dyah Astuti, Dian Ayu Risma, Andi Hamim Zaidan, Putri Suryaning Puspita; Photodynamic inactivation effect of laser diode on Staphylococcus aureus bacteria with exogenous photosensitizer nano doxycycline 0.1%. AIP Conf. Proc. 9 December 2020; 2314 (1): 060004. https://doi.org/10.1063/5.0034129
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