In this work features of propagation of electrical excitation waves in inhomogeneous anisotropic moving myocardium is considered. The conductivity values in different directions differ by an order of magnitude. The orientation of anisotropy axes significantly changes across the heart wall. Accounting for changes in the macroconductivity of the myocardium during its deformation is based on the analysis of its microstructure. The strain-activated channel (SAC) model is generalized for the case of triaxial strain under the following assumptions: the channels are evenly distributed over the cell surface or in t-tubules; the channels respond to a local increase in the area of the intercellular membrane site; the formula that uses elongation along the fiber is true for one-dimensional stretching along the fiber. Formulas are obtained for the cases of the arrangement of channels on the outer surface of the cell and in tubules. The fraction of stretched membrane regions where SAC can be activated was found.
The reported study was funded by RFBR and Perm Krai according to the research project N 19-41-590002
