The goal of the paper is to present the complete meshless solution procedure, i.e. without meshing or using the regular nodes in any part of the solution procedure, for a thermo-fluid problem governed by Navier-Stokes and heat equations. The core of the solution procedure is an approximation of differential operators with Radial basis function-generated finite differences (RBF- FD) meshless method, iterative pressure-velocity coupling, and implicit time stepping. The flexibility of the presented solution procedure and its implementation is demonstrated by solving a natural convection problem in 2D and 3D irregular domains on scattered nodes. The results, presented in terms of maximal cross-section velocities, are compared against available published data, with good agreement achieved.

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