The present study was conducted to evaluate and compare the biocompatibility of cranberry and grape seed extract as intracanal medicaments (ICM). Gel form of intracanal medicaments were formulated using cranberry and grape seed extract to which carbopol was added as a biocompatible polymer. Formulated intracanal medicaments were evaluated for biocompatibility and compared with commercially available Chlorhexidine gel intracanal medicament. Intracanal medicaments were divided into four study groups i.e., Group I containing cranberry ICM, GroupII containing grape seed ICM, Group III containing chlorhexidene gel, and Group IV containing saline as control, for the evaluation of biocompatibility property using MTT (3-(4) 5-Dimethyl-thiazol-Zyl) - 2,5 biphenyl tetrazolium bromide) assay. The present study suggests that ICM containing Grape seed extract (67.08%) showed least cell inhibition followed by cranberry extract ICM(73.37%) and chlorhexidene gel ICM (78.71%) at maximum concentration of 320mg/ml. ICM containing Grape seed extract and cranberry extract showed good biocompatibility and can be used as alternate to commercially available chlorhexidine gel ICM.

Topics
Biomaterials, Educational assessment
1.
Murvindran
,
V.
 and
Raj
,
J.D.
 
Journal of Pharmaceutical Sciences and Research
,
6
(
9
),
297
(
2014
).
Google Scholar
 
2.
Prabhakar
,
A.R.
,
Taur
,
S.
,
Hadakar
,
S.
 and
Sugandhan
,
S.
,
International Journal of Clinical Pediatric Dentistry
,
6
(
3
),
171
(
2013
).
https://doi.org/10.5005/jp-journals-10005-1213
Google Scholar
Crossref
Search ADS
PubMed
 
3.
Zhu
,
F.
,
Du
,
B.
 and
Li
,
J.
,
International Journal of Wine Research
,
7
,
63
(
2015
).
https://doi.org/10.2147/IJWR.S76162
Google Scholar
Crossref
Search ADS
 
4.
Jurikova
,
T.
,
Skrovankova
,
S.
,
Mlcek
,
J.
,
Balla
,
S.
 and
Snopek
,
L.
,
Molecules
,
24
(
1
),
24
(
2019
).
https://doi.org/10.3390/molecules24010024
Google Scholar
Crossref
Search ADS
 
5.
SILVA
,
A.P.P.D.
,
Goncalves
,
R.S.
,
Borges
,
A.F.S.
,
Bedran-Russo
,
A.K.
 and
Shinohara
,
M.S.
,
Journal of Applied Oral Science
,
23
(
3
),
302
–
309
(
2015
).
https://doi.org/10.1590/1678-775720140304
Google Scholar
Crossref
Search ADS
PubMed
 
6.
Xie
,
Q.
,
Bedran-Russo
,
A.K.
 and
Wu
,
C.D.
,
Journal of Dentistry
,
36
(
11
),
900
–
906
(
2008
).
https://doi.org/10.1016/j.jdent.2008.07.011
Google Scholar
Crossref
Search ADS
PubMed
 
7.
Gonzalez
,
R.J.
 and
Tarloff
,
J.B.
,
Toxicology in vitro
,
15
(
3
),
257
–
259
(
2001
).
https://doi.org/10.1016/S0887-2333(01)00014-5
Google Scholar
Crossref
Search ADS
PubMed
 
8.
Razmaraii
,
N.
,
Babaei
,
H.
,
Mohajjel
,
A.N.
,
Ahdi
,
S.K.
 and
Farajnia
,
S.
,
Archives of Razi Institute
,
72
(
3
),
181
–
187
(
2017
).
Google Scholar
PubMed
 
9.
Mustarichie
,
R.
,
Udin
,
Z.
,
Muhtadi
,
A.
,
Surahman
,
E.
,
Subarnas
,
A.
 and
Supriyatna
,
S.
,
Int Res J Pharm Appl Sci
,
2
(
4
),
56
–
61
(
2012
).
Google Scholar
 
10.
Mohammadi
,
Z.
 and
Abbott
,
P.V.
,
International endodontic journal
,
42
(
4
),
288
–
302
(
2009
).
https://doi.org/10.1111/j.1365-2591.2008.01540.x
Google Scholar
Crossref
Search ADS
PubMed
 
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