Curcuma caesia commonly known as Black turmeric exhibits high medicinal properties due to the presence of bioactive compounds. The rhizomes of Curcuma caesia was extracted with organic solvent such as ethanol using cold percolation method. The main objective of this study was carried out in order to find the best suitable condition for the extraction of total polyphenols. Total polyphenols are compounds which includes flavonoids, phenolic acids, stilbenes and lignans. The effects of extraction of total polyphenols involving extraction time, particle size and L/S ratio were evaluated and optimized using Box-Behnken design (BDD) a well-known response surface methodology. The results obtained from the experiments were subjected to analysis of variance (ANOVA) and analysed using polynomial equation. From the results, it was found that further optimization studies need to be carried out for effective extraction of total polyphenols.
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