L-type calcium channel (LTCC) gene Cav1.2 on astrocytes play an essential role in the alteration of Ca2+ homeostasis and a line of calcium-related glial-cell functions and neuro-glial dialogue. A wealth of experiment revealed that oxidative stress and reactive astrogliosis account for most neurological diseases. Existing studies shows oxidative stress induces influx of Ca2+ into the cell through LTCC. In this study, we directly investigated the effect of oxidative stress inducing by hydrogen peroxide (H2O2) on LTCC Cav1.2 α1-subunit. We found that H2O2 upregulated LTCC Cav1.2 α1-subunit protein but not mRNA, suggesting H2O2-induced changes in Cav1.2 α1-subunits most likely through posttranscriptional mechanism.
REFERENCES
1.
G.W.
Zamponi
, et al., Pharmacol Rev
, 67
, 821
–870
(2015
).2.
F.
Hofmann
, V.
Flockerzi
and S.
Kahl
. Physiol Rev
94
, 303
–326
(2014
).3.
A.
Catterall
, Annu Rev Cell Dev Biol
, 16
, 521
–555
(2000
).4.
F.
Hofmann
, M.
Biel
and V.
Flockerzi
, Annu Rev Neurosci
, 17
, 399
–418
(1994
).5.
M.
D'Ascenzo
, et al., Glia
45
, 354
–363
(2004
).6.
J.
Sibille
, et al., Front Cell Neurosci.
9
, 189
(2015
).7.
C.E.
Bond
and S.A.
Greenfield
, Glia
, 55
, 1348
–1361
(2007
).8.
L.
He
, X.
Hu
and Y.
Lai
, J. Mol. Neurosci.
2
,205
–213
(2016
).9.
R.
Westenbroek
, J. Neurosci.
18
, 2321
–2334
(1998
).10.
J.
Drake
, C.D.
Link
and D.A.
Butterfield
, Neurobiol. Aging
24
, 415
–420
(2003
).11.
Y.H.
Chunga
, et al., Neuroscience Letters
2001
, 93
–96
(2001
).
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