E-learning services are ’weapons’ or ’tools’ that are very powerful in college education in the 21st century. The characteristics of e-learning are students who need to learn and seek as much information as possible. The purpose of implementing e-learning in essential oil chemistry lectures which is supported by practicum is to improve understanding, attitudes and skills of students to be better because of the more combinative and interesting learning resources and complete both theory and practice. The effectiveness of the application of e-learning are measured by several indicators including the availability of core and supporting media for e-learning, the level of achievement of course learning outcomes AT1301-AT2002 with a good predicate as minimum, and the level of student satisfaction. The evaluation results obtained showed that 100% of the core media and learning support had been uploaded on Google classroom and the level of achievement of course learning outcomes AT1301 - AT2002 with a good predicate obtained more than 96%. However, the level of satisfaction of students is quite low at 58.5%. This is because understanding the online lecture itself is not fully understood by students and this is the first time they have attended in e-learning. In general, it can be concluded that online learning in essential oil chemistry lectures cannot be used as a role model for online learning in Chemistry Study Program because understanding the online lecture itself is not fully understood by students, this method can facilitate learning achievement, and this method can generate good character from students in terms of participation, problem solving, knowledge and skills.

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